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Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.
- H. Tanaka, K. Kannari, T. Maeda, M. Tomiyama, T. Suda, M. Matsunaga
- Biology, ChemistryNeuroreport
- 25 February 1999
It is suggested that serotonergic terminals in the striatum can convert exogenously administered L-DOPA into DA that can be released into the extracellular space.
Activation of 5‐HT1A but not 5‐HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered l‐DOPA in the striatum with nigrostriatal denervation
- K. Kannari, Hiroshi Yamato, H. Shen, M. Tomiyama, Toshihiro Suda, M. Matsunaga
- Biology, ChemistryJournal of neurochemistry
- 1 March 2001
The hypothesis that serotonergic neurons are primarily responsible for the storage and release of DA derived from exogenous l‐DOPA in the absence of dopaminergic neurons is supported.
A serotonin 5-HT1A receptor agonist prevents behavioral sensitization to l-DOPA in a rodent model of Parkinson's disease
[Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease].
- K. Kannari, K. Kurahashi, M. Matsunaga
- Psychology, MedicineNo to shinkei = Brain and nerve
- 1 February 2002
Tandospirone is effective in alleviating L-DOPA-induced dyskinesia in 50% of the patients, however, at the same time 50% patients showed slight worsening of parkinsonian features.
Rapid induction of serotonergic hyperinnervation in the adult rat striatum with extensive dopaminergic denervation
Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats.
- H. Shen, K. Kannari, Hiroshi Yamato, A. Arai, M. Matsunaga
- Biology, ChemistryThe Tohoku journal of experimental medicine
- 1 March 2003
It is suggested that benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA.
Generation of symptomatic palatal tremor is not correlated with inferior olivary hypertrophy.
The appearance of SPT may depend on the hyperactivity of olivary neurones released from inhibitory inputs until the peak of both IOH and SPT, which is probably due to both the disturbance of natural rhythmicity in the body and the lack of feedback from the abnormal movement resulting from the dysfunction of the olive.
Sympathetic skin response in healthy man.
Topography of Alzheimer's neurofibrillary change distribution in myotonic dystrophy.
- N. Yoshimura, M. Otake, K. Igarashi, M. Matsunaga, K. Takebe, H. Kudo
- BiologyClinical neuropathology
- 1 September 1990
It is suggested that the presence of ANCs concentrated mostly in the limbic system is a regular and significant histological finding in the brain in MD, and must be related to some of the mental symptoms unique to MD.
Sympathetic skin response in diabetic neuropathy.
- Y. Watahiki, M. Baba, M. Matsunaga, K. Takebe, T. Onuma
- MedicineElectromyography and clinical neurophysiology
- 1 April 1989
Most of the patients with clinical evidence of dysautonomia and with insulin treatment revealed diminished or absent SSR, indicating a close correlation between the disturbance of sudomotor function and that of other sympathetic and parasympathetic functions.