Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor.
Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor.
The results show that HORK3 is a Gi/o-coupled receptor and that its natural ligand is ADP, and support the view that P2Y(1) functions as a high-affinity ADP receptor and P2T(AC) as a low-Affinity ADp receptor in platelets.
Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.
- S. Matsumoto, C. Yamazaki, Y. Shigeyoshi
- Biology, MedicineProceedings of the National Academy of Sciences…
- 14 March 2006
It is demonstrated that physiological activation of PKR2 is essential for normal development of the OB and sexual maturation.
Molecular cloning and characterization of another leukotriene B4 receptor.
It is found that leukotriene B(4) induced inhibition of forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells, stably expressing JULF2, a novel G protein-coupled receptor of 358 amino acids that shares 36.6% amino acid identity with human BLT.
An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.
The high sequence conservation and abundant expression in the central nervous system suggest the existence of undiscovered fundamental neuronal systems consisting of SREB family members and their endogenous ligand(s).
The Molecular Characterization and Tissue Distribution of the Human Cysteinyl Leukotriene CysLT2 Receptor
It is shown that the pharmacological profile of an orphan GPCR (PSEC0146) is consistent with that of the CysLT2 receptor, and in human embryonic kidney 293 cells that express the PSEC 0146 cDNA, leukotriene C4 (LTC4) and leukOTriene D 4 (LTD4) induce equal increases in intracellular calcium mobilization; these increases are not affected by Cys LT1 antagonists.
Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Functional characterization of cysteinyl leukotriene CysLT(2) receptor on human coronary artery smooth muscle cells.
- M. Kamohara, J. Takasaki, K. Furuichi
- Biology, MedicineBiochemical and biophysical research…
- 12 October 2001
This is the first report on the physiological role of CysLT(2), and the findings suggest that Cys LT(2) has biological significance in the cardiovascular system.
Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.