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Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
TLDR
A novel estimate of insulin sensitivity that is simple to calculate and provides a reasonable approximation of whole-body insulin sensitivity from the oral glucose tolerance test (OGTT).
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
TLDR
Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects.
Reduced Time Points to Calculate the Composite Index
TLDR
The composite (Matsuda) index for the measurement of insulin sensitivity from plasma glucose and insulin concentrations during the oral glucose tolerance test (OGTT) has been widely used by investigators throughout the world.
Bromocriptine: a novel approach to the treatment of type 2 diabetes.
TLDR
Bromocriptine improves glycemic control and glucose tolerance in obese type 2 diabetic patients and is associated with enhanced maximally stimulated insulin-mediated glucose disposal.
Metabolic effects of visceral fat accumulation in type 2 diabetes.
TLDR
In patients with established type 2 diabetes, VF accumulation has a significant negative impact on glycemic control through a decrease in peripheral insulin sensitivity and an enhancement of gluconeogenesis.
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
TLDR
Throughout the glucose tolerance range, dynamic parameters of beta-cell function (glucose sensitivity, rate sensitivity, and potentiation) and insulin sensitivity are independent determinants of 2-h plasma glucose levels.
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.
TLDR
Results demonstrate that a shift of fat distribution from visceral to sc adipose distribution improved after pioglitazone treatment, and is associated with improvements in hepatic and peripheral tissue sensitivity to insulin.
Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy.
TLDR
Results indicate that ELMO1 is a novel candidate gene that both confers susceptibility to DN and plays an important role in the development and progression of this disease.
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients
TLDR
The results suggest that the beneficial effects of rosiglitazone on glycaemic control are mediated, in part, by the drug's effect on NEFA metabolism.
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study
TLDR
When the plasma insulin response to oral glucose is related to the glycaemic stimulus and severity of insulin resistance, there is a progressive decline in beta-cell function that begins in “normal” glucose tolerant individuals.
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