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Clostridium perfringens Enterotoxin Utilizes Two Structurally Related Membrane Proteins as Functional Receptors in Vivo *
The results indicate that CPE uses structurally related cellular proteins as functional receptors in vivo and that organs that have not so far been recognized as CPE-sensitive have the potential to be targets of CPE.
Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin
It is proposed that the enterotoxin receptor is required for both target cell recognition and poreformation in the cell membrane.
Bordetella bronchiseptica dermonecrotizing toxin stimulates assembly of actin stress fibers and focal adhesions by modifying the small GTP-binding protein rho.
Results indicate that DNT causes the assembly of actin stress fibers and focal adhesions by directly modifying rho protein.
Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.
Results indicate that the toxin catalyzes deamidation of Gln-63 of Rho and renders it constitutively active, leading to formation of actin stress fibers.
System for the Investigation of the Bacteriophage-directed Synthesis of Diphtherial Toxin
The conditions of the experiment and the use of purified phage, free from toxin, support the conclusion that all of the toxin was newly formed, and this toxin was immunochemically indistinguishable from standard toxin produced by the PW8(r)(Pdi)(tox+) strain.
Intergranular bridges in the anterior pituitary cell and their possible involvement in Ca2+-induced granule-granule fusion
It is considered that the intergranular bridges, some of which may be composed of annexin II, are involved in Ca2+-induced granule-granule fusion in anterior pituitary cells.
Isolation and purification of two antigenically active, "complimentary" polypeptide fragments of tetanus neurotoxin
Immunodiffusion analyses, using horse antitoxin, showed that the antigenicities of fragment alpha and fragment beta were distinct from each other but were partially identical with that of undissociated toxin.
Antigenic substructure of tetanus neurotoxin.
Formation of Ring-Shaped Structures on Erythrocyte Membranes after Treatment with Botulinolysin, a Thiol-Activated Hemolysin from Clostridium botulinum
ABSTRACT Damage to erythrocyte membranes by botulinolysin (BLY) was studied by electron microscopy, which revealed ring-shaped structures with inner diameters and widths of approximately 32 and 6.7