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Pharmacokinetic study of different doses of Depo Provera.
The dose of MPA in the monthly injectable CycloProvera could be substantially reduced without loss of effectiveness and it is suggested that in the population studied, 100mg Depo provera would be as effective as the usual 150mg dose and that injection of 50mgdepoProversa would provide a contraceptive effect for two months. Expand
Medroxyprogesterone acetate in human serum.
The MPA levels in blood measured by radioimmunoassay were generally lower when serum was extracted with an organic solvent rather than when the assay was carried out directly in the serum, suggesting the presence in blood of either MPA in a conjugated form or metabolites interacting with the antiserum which were not extracted by the solvents used. Expand
A versatile assay for gelatinases using succinylated gelatin.
- V. Baragi, B. Shaw, +5 authors S. Rao
- Chemistry, Medicine
- Matrix biology : journal of the International…
- 1 July 2000
The assay combines ease and rapidity of assays based on synthetic peptide substrates with specificity of the gelatin zymography technique, suitable for measuring gelatinolytic activity of enzymes and high volume screening of MMP-2 and -9 inhibitors. Expand
Excretion of collagen derived peptides is increased in women with stress urinary incontinence
- L. Kushner, M. Mathrubutham, T. Burney, R. Greenwald, G. Badlani
- Neurourology and urodynamics
It is demonstrated that weakened pelvic floor support of the lower genitourinary tract in women with stress urinary incontinence (SUI) is due to increased collagenolysis. Expand
Development and validation of a fluorescence technology for both primary and secondary screening of kinases that facilitates compound selectivity and site-specific inhibitor determination.
- A. Morgan, T. J. Mccauley, Michael L. Stanaitis, M. Mathrubutham, S. Millis
- Chemistry, Medicine
- Assay and drug development technologies
- 5 July 2004
The IQ Technology has been developed to serve as a homogeneous, universal detection platform for HTS of kinases and phosphatases and provides a universal method that can be used with any peptide sequence and is insensitive to high concentrations of ATP. Expand
A versatile microassay for elastase using succinylated elastin.
- S. Rao, M. Mathrubutham, A. Karteron, K. Sorensen, J. Cohen
- Chemistry, Medicine
- Analytical biochemistry
- 1 August 1997
The use of succinylated elastin shows specificity for elastase over the control protease, trypsin, and this assay is also versatile because it can be applied to samples such as cell culture supernatants, blood plasma, tissue biopsies, and tissue homogenates. Expand
Reduced capacity to inhibit elastase in abdominal aortic aneurysm.
- S. Rao, M. Mathrubutham, D. Sherman, J. Cerveira, J. Cohen
- The Journal of surgical research
- 1 March 1999
There is a significant reduction in the plasma inhibitory capacity ofElastase in AAA patients in comparison to normal controls, though plasma elastase level was not significantly different. Expand
Generation of ordered phage sublibraries of YAC clones: construction of a 400-kb phage contig in the human dystrophin gene.
A phage contig of 400 kb that extends from the brain-specific promoter at the 5'-end of the human dystrophin gene, through the muscle-specific promoter over 100 kb further downstream, and across most… Expand
Plasma elastase activity inhibition--a microassay.
The inhibition assay is a modification of a technique recently developed by us, which detects the primary amines that are exposed because of the enzymatic degradation of elastin substrate, and evaluated the ability of plasma to inhibit purified elastase. Expand
Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays.
- D. Bassoni, Qumber Jafri, S. Sastry, M. Mathrubutham, T. Wehrman
- Medicine, Chemistry
- Methods in molecular biology
This chapter describes a nonradioactive, chemiluminescent cAMP detection method using enzyme fragment complementation technology to detect a wide range of GPCR modulators which is also suitable for high-throughput screening. Expand