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Pharmacological Evidence for a Role of ATP‐Dependent Potassium Channels in Myocardial Stunning
TLDR
The ability of apikalim and the KATP channel antagonists to alter postischemic wail function occurred independently of differences in systemic hemodynamics, area at risk, and collateral blood flow during occlusion, the major determinants of the extent of myocardial stunning.
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Cardioprotective Effects of Nicorandil
TLDR
The results of the present study suggest that nicorandil is a highly efficacious myocardial protective agent in several animal models of reversible or irreversible ischemia-reperfusion injury and its mechanism of action is unclear.
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The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes.
TLDR
The objective of the present study was to determine the effect of a novel K+ channel opener, Aprikalim, on myocardial infarct size in barbital-anesthetized dogs subjected to 90 min of left circumflex coronary artery occlusion followed by 5 hr of reperfusion.
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Modification by Islet‐Activating Protein of Direct and Indirect Inhibitory Actions of Adenosine on Rat Atrial Contraction in Relation to Cyclic Nucleotide Metabolism
TLDR
It is indicated that adenosine produces a dual action on rat atria: it decreases the force of contraction directly by a mechanism independent of cyclic AMP metabolism, and inhibits the positive inotropic action of isoproterenol by reducing the drug-induced accumulation of cyclIC AMP.
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Mode and mechanism of action of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, on the dog heart.
TLDR
In heart-lung preparations OPC -8212 improved cardiac function depressed with pentobarbital, and caused bradycardia, and in trabecular muscles of the right ventricle OPC-8212 produced a concentration-dependent positive inotropic effect in the presence of the beta 1-adrenoceptor antagonist, atenolol.
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Characterization of MS-857, a New and Potent Cardiotonic Agent, in Isolated Mammalian Cardiac Muscles
TLDR
Findings support the idea that cyclic AMP may be involved in the positive inotropic effect of MS-857.
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Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart.
TLDR
Results indicate that IAP treatment attenuates the inhibitory actions of carbachol elicited via muscarinic receptors through both cAMP-dependent andcAMP-independent subcellular processes.
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Effects of Hydroxyethyl Starch Conjugated Deferoxamine on Myocardial Functional Recovery Following Coronary Occlusion and Reperfusion in Dogs
TLDR
High-molecular-weight HES-DFO is effective in enhancing the recovery of regional wall motion in stunned myocardium and the reason for the lack of efficacy of DFO compared to HES -DFO at this high dose may be related to the formation of a toxic deferoxamine free radical species.
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Cardiovascular Properties of MS‐857, a New and Potent Cardiotonic Agent, on Normal and Failing Hearts
TLDR
MS-857 can be characterized as a potent nonsympathomimetic, nonglycoside cardiotonic drug with a selective inhibitory activity on PDE III with a beneficial effect in the treatment of congestive heart failure.
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Profile of Cardiac and Coronary Vasodilator Effects of MS-857, a Novel Cardiotonic Agent, Assessed in Isolated, Blood-Perfused Heart Preparations of the Dog
TLDR
At doses which MS-857 produced a 50% increase in developed tension of papillary muscle, the drug also produces coronary vasodilatation with minimal chronotropic and dromotropic effects and resembles both milrinone and MCI-154 among few cardiotonic agents.
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