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Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines
The effects of supernatant from the bacterial strain Serratia marcescens 2170 (CS‐2170) on the viability of different haematopoietic cancer cell lines (Jurkat, NSO, HL‐60 and Ramos) and nonmalignantExpand
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DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin.
Prodigiosin is a red pigment produced by Serratia marcescens with apoptotic activity. We examined the mechanism of action of this tripyrrole alkaloid, focusing on its interaction with DNA and itsExpand
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Rapid response to osmotic upshift by osmoregulated genes in Escherichia coli and Salmonella typhimurium.
The rapid in vivo response of both Escherichia coli and Salmonella typhimurium osmoregulated genes to an osmotic upshift was analyzed in detail by using chromosomal operon fusions. Within 10 minExpand
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ENPDA: an evolutionary structure-based de novo peptide design algorithm
We propose an evolutionary tool for de novo peptide design, based on the evaluation of energies for peptide binding to a user-defined protein surface patch. Expand
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Nocturnal pollination of the endemic Silene sennenii (Caryophyllaceae): an endangered mutualism?
Silene sennenii is an extremely narrow endemic species from the north-eastern Iberian Peninsula, with only five populations. Its habitat, severely affected by urban, industrial, and agricultural landExpand
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Synthetic Ligands Able to Interact with the P53 Tetramerization Domain. Towards Understanding a Protein Surface Recognition Event
The applied interaction of synthetic molecules with defined regions of protein surfaces is an emerging strategy for the modulation of protein activity and/or stability. In spite of recent advances,Expand
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The ‘paradigm of extremes’: extremely low genetic diversity in an extremely narrow endemic species, Coristospermum huteri (Umbelliferae)
Low levels of genetic diversity in endemic species are generally attributable to the small size of their populations. This lack of genetic variability will, predictably, be more evident in thoseExpand
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Low genetic variability in the rare, recently differentiated Aquilegia paui (Ranunculaceae)
Aquilegia paui is a narrow endemic species from the north-eastern Iberian Peninsula. It has a reduced number of populations in the limestone mountain massif of Els Ports. Genetic diversity wasExpand
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Shift towards autogamy in the extremely narrow endemic Aquilegia paui and comparison with its widespread close relative A. vulgaris (Ranunculaceae)
Aquilegia paui is an extremely narrowly endemic species from the northeastern Iberian Peninsula. It is restricted to a few populations with a reduced number of individuals living in summit rockExpand
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Genetic diversity in Silene sennenii Pau (Caryophyllaceae) assayed through DNA-based techniques
GENETIC dIVERSITY IN Silene Sennenii PAU (CARYOPHYLLACEAE) ASSAYEd THROUGH dNA-BASEd TECHNIqUES.— Silene sennenii is a narrow endemic species from the NE of the Iberian Peninsula. It is considered asExpand
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