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Information deficits in the summary of product characteristics preclude an optimal management of drug interactions: a comparison with evidence from the literature
ObjectiveTo compare comprehensiveness and accuracy of drug interaction information in the German summary of product characteristics (SPC) with current evidence from the literature and to evaluate theExpand
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Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL.
AIMS Bioavailability of orally administered drugs depends on several factors including active excretion, e.g. by P-glycoprotein (PGP), and presystemic metabolism, e.g. by cytochrome P450 3A (CYP3A),Expand
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Drug dosage in patients with renal failure optimized by immediate concurrent feedback
AbstractOBJECTIVE: To examine the impact of immediate concurrent feedback on dose adjustment in patients with renal failure. DESIGN: Prospective 12-month study in patients with various degrees ofExpand
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Case Report: A Drug Database Model as a Central Element for Computer-Supported Dose Adjustment within a CPOE System
The incidence of adverse drug reactions may be decreased by computerized physician order entry (CPOE) with decision support. Expand
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Quality markers of drug information on the Internet: an evaluation of sites about St. John's wort.
PURPOSE We aimed to evaluate websites about St. John's wort for the quality of their content, including accuracy as reflected by statement of correct indication and mentioning of interacting drugs,Expand
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Oral contraception does not alter single dose saquinavir pharmacokinetics in women.
AIMS Women experience more adverse drug reactions (ADR) to antiretroviral therapy than men. This may be attributed to higher plasma concentrations of protease inhibitors due to pharmacokineticExpand
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Undeclared exposure to St. John's Wort in hospitalized patients.
AIM The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co-administered drugs. Therefore, we evaluated the extent of systemic exposure toExpand
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Dose individualisation in patients with renal insufficiency: does drug labelling support optimal management?
ObjectiveAn important information source for pharmacotherapy in populations at risk is drug labelling. We compared the recommendations for patients with renal insufficiency included in German drugExpand
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Quality of drug information on the World Wide Web and strategies to improve pages with poor information quality. An intervention study on pages about sildenafil.
AIMS The generally poor quality of health information on the world wide web (WWW) has caused preventable adverse outcomes. Quality management of information on the internet is therefore criticalExpand
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High prevalence of unknown co-medication in hospitalised patients
ObjectiveCo-medication unknown to the treating physician, including self-medication, may compromise drug safety by increasing the risk of duplicate therapy, drug interactions and adverse drugExpand
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