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- Publications
- Influence
Genome sequencing in microfabricated high-density picolitre reactors
- M. Margulies, M. Egholm, +53 authors J. M. Rothberg
- Biology, Medicine
- Nature
- 15 September 2005
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing… Expand
The complete genome of an individual by massively parallel DNA sequencing
- D. Wheeler, M. Srinivasan, +24 authors J. M. Rothberg
- Biology, Medicine
- Nature
- 17 April 2008
The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. However, the… Expand
Genome Sequencing in Open Microfabricated High Density Picoliter Reactors
- M. Margulies, M. Egholm, +61 authors J. Rothberg
- 2005
We describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel… Expand
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- PDF
Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
- M. Margulies, M. Egholm, +60 authors J. M. Rothberg
- Biology
- Nature
- 2006
This corrects the article DOI: 10.1038/nature03959
Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
- M. Margulies, M. Egholm, +60 authors J. M. Rothberg
- Biology, Art
- Nature
- 26 January 2006
This corrects the article DOI: 10.1038/nature03959
Computer training for doctors and students
- T. D. Dombal, S. Clamp, M. Margulies, M. Chan
- Computer Science, Medicine
- BMJ
- 5 November 1994
TLDR
Chapter 5 The 454 Life Sciences Picoliter Sequencing System
- M. Margulies, T. Jarvie, J. R. Knight, J. F. Simons
- Biology
- 2007
Abstract We describe a novel sequencing system with a 100-fold improvement in throughput over state-of-the-art capillary electrophoresis instruments. The apparatus uses a single 60×60 mm 2 fiber… Expand
Dynamic differential scanning calorimetry
- M. Divito, R. Cassel, M. Margulies, S. Goodkowsky
- Chemistry
- 1995
- 3
On-orbit performance of the Hubble Space Telescope fine guidance sensors.
- D. Eaton, R. A. Whittlesey, B. W. Allen, R. Stoll, L. Abramowicz-Reed, M. Margulies
- Physics, Medicine
- Applied optics
- 1 April 1993
The observed and measured on-orbit performance of various aspects of the fine guidance sensors is presented and discussed in the light of the original requirements and predictions. The fine guidance… Expand
Dynamics analyses provide insight into the influence of precore mutations on the mechanisms of viral CL
- E. J. Heathcote, Q. Thai, +8 authors C. Brosgart
- Medicine
- 1 April 2001