M. Margulies

Publications28
h-index7
Citations9,375
Highly Influential Citations447
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Genome sequencing in microfabricated high-density picolitre reactors
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing… Expand
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The complete genome of an individual by massively parallel DNA sequencing
The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. However, the… Expand
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Genome Sequencing in Open Microfabricated High Density Picoliter Reactors
We describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel… Expand
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Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
This corrects the article DOI: 10.1038/nature03959
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Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
This corrects the article DOI: 10.1038/nature03959
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Computer training for doctors and students
TLDR
We agree with the comments by Ronald LaPorte and colleagues1 and Ray Jones and Sue Kinn. Expand
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Chapter 5 The 454 Life Sciences Picoliter Sequencing System
Abstract We describe a novel sequencing system with a 100-fold improvement in throughput over state-of-the-art capillary electrophoresis instruments. The apparatus uses a single 60×60 mm 2 fiber… Expand
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Dynamic differential scanning calorimetry
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On-orbit performance of the Hubble Space Telescope fine guidance sensors.
The observed and measured on-orbit performance of various aspects of the fine guidance sensors is presented and discussed in the light of the original requirements and predictions. The fine guidance… Expand
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Dynamics analyses provide insight into the influence of precore mutations on the mechanisms of viral CL
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