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Genome sequencing in microfabricated high-density picolitre reactors
TLDR
A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.
The complete genome of an individual by massively parallel DNA sequencing
TLDR
This sequence was completed in two months at approximately one-hundredth of the cost of traditional capillary electrophoresis methods and demonstrated the acquisition of novel human sequence, including novel genes not previously identified by traditional genomic sequencing, which is the first genome sequenced by next-generation technologies.
Genome Sequencing in Open Microfabricated High Density Picoliter Reactors
We describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel
Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
TLDR
This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance”, which is a type of “plague” found in the immune system.
Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
TLDR
This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance”, which is a type of “plague” found in the immune system.
Chapter 5 The 454 Life Sciences Picoliter Sequencing System
TLDR
A novel sequencing system with a 100-fold improvement in throughput over state-of-the-art capillary electrophoresis instruments, it is predicted that the system's inherent scalability will lead to two additional orders of magnitude improved in throughput, possibly enabling routine sequencing of individual human genomes.
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