6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
- M. Marder, H. Viola, C. Wasowski, Sebastian P. Fernandez, J. Medina, A. Paladini
- BiologyPharmacology, Biochemistry and Behavior
- 1 June 2003
Central nervous system depressant action of flavonoid glycosides.
- Sebastian P. Fernandez, C. Wasowski, M. Marder
- Biology, ChemistryEuropean Journal of Pharmacology
- 13 June 2006
Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds
- A. Paladini, M. Marder, H. Viola, C. Wolfman, C. Wasowski, J. Medina
- ChemistryThe Journal of pharmacy and pharmacology
- 1 May 1999
Semisynthetic derivatives of flavone obtained by introducing halogens, nitro groups or both in its molecule give rise to high affinity ligands for the benzodiazepine receptor, active in‐vivo; 6,3′‐dinitroflavone, for example, is an anxiolytic drug 30 times more potent than diazepam.
Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
- Sebastian P. Fernandez, C. Wasowski, A. Paladini, M. Marder
- BiologyPharmacology, Biochemistry and Behavior
- 1 February 2004
GABA(A)-receptor ligands of flavonoid structure.
- M. Marder, A. Paladini
- Chemistry, BiologyCurrent Topics in Medicinal Chemistry
- 31 July 2002
The new research developments that have established the CNS-activity of some natural flavonoids are described and a survey of the occurrence of ligands for the benzodiazepine binding site in the flavonoid field is attempted.
Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands
- J. Medina, H. Viola, A. Paladini
- Biology, ChemistryNeurochemical Research
- 1 April 1997
Flavonoid derivatives, such as 6,3′-dinitroflavone were found to have a very potent anxiolytic effect not associated with myorelaxant, amnestic or sedative actions, and could represent an improved therapeutic tool in the treatment of anxiety.
Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii.
- C. Wasowski, M. Marder, H. Viola, J. Medina, A. Paladini
- Biology, ChemistryPlanta Medica
- 1 October 2002
Using the guidance by a competitive assay for the benzodiazepine binding site in the GABA(A) receptor, active compounds were isolated from the rhizomes and roots of Valeriana wallichii DC. The UV,…
Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.
- Sebastian P. Fernandez, C. Wasowski, A. Paladini, M. Marder
- Chemistry, BiologyEuropean Journal of Pharmacology
- 11 April 2005
Flavonoids as GABAA receptor ligands: the whole story?
- C. Wasowski, M. Marder
- BiologyJournal of Experimental Pharmacology
- 23 February 2012
Flavonoids are prominent drugs in the treatment of mental disorders, and can also be used as tools to study modulatory sites at GABA type A receptors and to develop GABAtype A selective agents further.
6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.
- M. Marder, H. Viola, A. Paladini
- Biology, ChemistryBiochemical and Biophysical Research…
- 14 June 1996
6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki=70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg i.p. A survey of the…
...
...