M. Marder

Publications56
h-index24
Citations2,352
Highly Influential Citations77
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6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
Valerian is an ancient tranquillizing drug obtained from the underground organs of several Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or… Expand
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Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
Galectins control critical pathophysiological processes, including the progression and resolution of central nervous system (CNS) inflammation. In spite of considerable progress in dissecting their… Expand
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Central nervous system depressant action of flavonoid glycosides.
The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explored and compared to those of the glycosides 2S-hesperidin and linarin, recently… Expand
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Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds
The list of activities of plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when our laboratory described the existence of natural anxiolytic flavonoids. The… Expand
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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and… Expand
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Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii.
Using the guidance by a competitive assay for the benzodiazepine binding site in the GABA(A) receptor, active compounds were isolated from the rhizomes and roots of Valeriana wallichii DC. The UV,… Expand
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6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.
6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki=70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg i.p. A survey of the… Expand
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Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.
It has been recently reported the presence in Valeriana of the flavone 6-methylapigenin and the flavanone glycoside hesperidin. The apigenin derivative is a ligand for the benzodiazepine binding site… Expand
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Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination
Galectin-3 (Gal-3) is a β-galactoside-binding lectin that plays an important role in inflammatory and neurodegenerative diseases. Cuprizone (CPZ)-induced demyelination is characterized by the loss of… Expand
  • 38
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GABA(A)-receptor ligands of flavonoid structure.
This review describes the new research developments that have established the CNS-activity of some natural flavonoids. The properties of flavone, chrysin, apigenin and cirsiliol are described and a… Expand
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