Development of Monocytes, Macrophages, and Dendritic Cells
- F. Geissmann, M. Manz, Steffen Jung, M. Sieweke, M. Merad, K. Ley
- BiologyScience
- 5 February 2010
The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice.
Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice
- E. Traggiai, L. Chicha, M. Manz
- Biology, MedicineScience
- 2 April 2004
It is shown that intrahepatic injection of CD34+ human cord blood cells into conditioned newborn Rag2-/–γc–/– mice leads to de novo development of B, T, and dendritic cells; formation of structured primary and secondary lymphoid organs; and production of functional immune responses.
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.
- C. Jamieson, L. Ailles, I. Weissman
- Biology, MedicineNew England Journal of Medicine
- 12 August 2004
Activation of beta-catenin in CML granulocyte-macrophage progenitors appears to enhance the self-renewal activity and leukemic potential of these cells.
Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
- N. Onai, Aya Obata-Onai, M. A. Schmid, T. Ohteki, D. Jarrossay, M. Manz
- Biology, MedicineNature Immunology
- 7 October 2007
This work identifies highly cycling Lin−c-KitintFlt3+M-CSFR+ cells with a distinct gene-expression profile in mouse bone marrow that efficiently generated plasmacytoid and conventional DCs but no other lineages, which increased in number after in vivo injection of the cytokine Flt3 ligand.
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
- H. Karsunky, M. Merad, A. Cozzio, I. Weissman, M. Manz
- BiologyJournal of Experimental Medicine
- 21 July 2003
It is shown that common lymphoid and common myeloid progenitors, as well as steady state DCs in thymus, spleen, and epidermis, express Flt3, and it is demonstrated that FlT3L can drive DC development along both the lymphoids and myeloids developmental pathways from Flt 3+ progenitor cells and their progeny DCs.
Biology of hematopoietic stem cells and progenitors: implications for clinical application.
- M. Kondo, A. Wagers, I. Weissman
- BiologyAnnual Review of Immunology
- 28 November 2003
Recent rapid advances in understanding the biological nature of hematopoietic stem and progenitor cells have broadened the potential application of these cells in the treatment of diseases.
Prospective isolation of human clonogenic common myeloid progenitors
- M. Manz, T. Miyamoto, K. Akashi, I. Weissman
- BiologyProceedings of the National Academy of Sciences…
- 22 August 2002
The prospective isolation of early developmental intermediates, the human clonogenic common myeloid progenitors and their downstream progeny, the granulocyte/macrophage and megakaryocyte/erythrocyte progenitor populations are shown.
Emergency granulopoiesis
- M. Manz, S. Boettcher
- Biology, MedicineNature reviews. Immunology
- 2014
This Review discusses the molecular and cellular events that regulate emergency granulopoiesis, a process that is crucial for host survival and involves the markedly increased de novo production of neutrophils, which results from enhanced myeloid precursor cell proliferation in the bone marrow.
Langerhans cells renew in the skin throughout life under steady-state conditions
- M. Merad, M. Manz, E. Engleman
- MedicineNature Immunology
- 2003
In the December 2002 issue of Nature Immunology, incorrect versions of Figures 1f and 4g were supplied and the correct versions are shown below.
Development and function of human innate immune cells in a humanized mouse model
- A. Rongvaux, T. Willinger, R. Flavell
- Biology, MedicineNature Biotechnology
- 16 March 2014
Two mouse strains called MITRG and MISTRG are described, in which human versions of four genes encoding cytokines important for innate immune cell development are knocked into their respective mouse loci, which may enable evaluation of therapeutic candidates in an in vivo setting relevant to human physiology.
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