M. Manz

Publications313
h-index63
Citations20,714
Highly Influential Citations852
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Development of Monocytes, Macrophages, and Dendritic Cells
TLDR
The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice. Expand
Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice
TLDR
It is shown that intrahepatic injection of CD34+ human cord blood cells into conditioned newborn Rag2-/–γc–/– mice leads to de novo development of B, T, and dendritic cells; formation of structured primary and secondary lymphoid organs; and production of functional immune responses. Expand
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.
TLDR
Activation of beta-catenin in CML granulocyte-macrophage progenitors appears to enhance the self-renewal activity and leukemic potential of these cells. Expand
Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
TLDR
This work identifies highly cycling Lin−c-KitintFlt3+M-CSFR+ cells with a distinct gene-expression profile in mouse bone marrow that efficiently generated plasmacytoid and conventional DCs but no other lineages, which increased in number after in vivo injection of the cytokine Flt3 ligand. Expand
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
TLDR
It is shown that common lymphoid and common myeloid progenitors, as well as steady state DCs in thymus, spleen, and epidermis, express Flt3, and it is demonstrated that FlT3L can drive DC development along both the lymphoids and myeloids developmental pathways from Flt 3+ progenitor cells and their progeny DCs. Expand
Biology of hematopoietic stem cells and progenitors: implications for clinical application.
TLDR
Recent rapid advances in understanding the biological nature of hematopoietic stem and progenitor cells have broadened the potential application of these cells in the treatment of diseases. Expand
Prospective isolation of human clonogenic common myeloid progenitors
TLDR
The prospective isolation of early developmental intermediates, the human clonogenic common myeloid progenitors and their downstream progeny, the granulocyte/macrophage and megakaryocyte/erythrocyte progenitor populations are shown. Expand
Dendritic cell homeostasis.
TLDR
This review integrates recent knowledge on DC progenitors, cytokines, and transcription factor usage to an emerging concept of in vivo DC homeostasis in steady-state and inflammatory conditions and highlights how knowledge of these maintenance mechanisms might impact on understanding of DC malignancies as well as posttransplant immune reactions and their respective therapies. Expand
Langerhans cells renew in the skin throughout life under steady-state conditions
TLDR
It is shown that in lethally irradiated mice that had received BM transplants, LCs of host origin remained for at least 18 months, whereas DCs in other organs were almost completely replaced by donor cells within 2 months. Expand
The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis.
TLDR
The concerted action of GM-CSF and Flt3-ligand on DC homeostasis in vivo is shown and T-cell and antigen-specific IgG responses decline progressively, from wild-type to GM- CSF- to Flt 3-ligands- to double-deficient mice, upon subcutaneous antigen delivery. Expand
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