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Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report
It is shown that the prevalence of anti-SARS-CoV-2 Igs for the period June–July 2020 remained low and provides knowledge of public health importance for the NKUA members.
Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing
Those natural compounds that have been found to activate proteostatic and/ or anti-stress cellular responses and hence have the potential to delay cellular senescence and/or in vivo ageing are reviewed.
Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach
The mechanistic connections between nutrition and aging in Drosophila is discussed, and how this model organism can be used to study the effect of different diets on higher metazoans longevity.
Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage
An analysis of the perforin-like protein 4, PPLP4, in the rodent parasite Plasmodium berghei found that the protein is expressed only in the ookinete, the invasive stage of the parasite formed in the mosquito midgut.
Is the shortened dental arch still a satisfactory option?
Evidence that the SDA causes pathology is lacking and the concept remains viable particularly for the medically compromised patient or where restorations are considered unsuitable but further more specific studies are warranted.
Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes
In vivo findings highlight the critical role of the Parkin/Pink1 pathway in mitophagy, and support the therapeutic potency of Nrf2 (a druggable pathway) activation in age-related degenerative diseases.
SARS-CoV-2 Infection Is Asymptomatic in Nearly Half of Adults with Robust Anti-Spike Protein Receptor-Binding Domain Antibody Response
The high percentage of unsuspected/asymptomatic active cases, which may contribute to community transmission for more days than that of cases who are aware and self-isolate, underscores the necessity of measures across the population for the efficient control of the pandemic.
Kinetics of anti‐SARS‐CoV‐2 neutralizing antibodies development after BNT162b2 vaccination in patients with amyloidosis and the impact of therapy
This work has shown clear trends in progeria-related death in older people with dementia, and these trends are likely to be driven by age, disease severity, and underlying causes.
Alterations in Organismal Physiology, Impaired Stress Resistance, and Accelerated Aging in Drosophila Flies Adapted to Multigenerational Proteome Instability
- M. Manola, Eleni N. Tsakiri, I. Trougakos
- BiologyOxidative medicine and cellular longevity
- 11 June 2019
Multigenerational proteotoxic stress in OregonR flies induced by constant exposure to developmentally nonlethal doses of the proteasome inhibitor bortezomib increased proteome instability and redox imbalance, reduced fecundity and body size, and caused neuromuscular defects; it also accelerated aging.
Comparison of Neutralizing Antibody Responses at 6 Months Post Vaccination with BNT162b2 and AZD1222
Comparisons of SARS-CoV-2 neutralizing antibody (NAb) levels at one, three and six months after second vaccination with the BNT162b2 mRNA vaccine and the ChAdOx1 (AZD1222) viral vector vaccine may inform public health policies regarding the timing of booster COVID-19 vaccine shots.