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Motility-driven glass and jamming transitions in biological tissues.
TLDR
A self-propelled Voronoi (SPV) model is studied that simultaneously captures polarized cell motility and multi-body cell-cell interactions in a confluent tissue, where there are no gaps between cells, and precisely captures a jamming transition from a solid-like state to a fluid- like state.
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A density-independent rigidity transition in biological tissues
TLDR
A new type of rigidity transition implicates the physical properties of the cells and resembles that of active particles jamming at a critical density—but the tissue density stays constant.
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Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
TLDR
The minimal model successfully explains the available experimental data and makes predictions, based on the feedback between mechanical energy and geometry, about the shapes of aggregate surface cells, which are verified experimentally.
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A geometrically controlled rigidity transition in a model for confluent 3D tissues
TLDR
It is demonstrated that, unlike jamming in soft spheres, residual stresses are necessary to create rigidity, and it is conjecture that there is a well-defined minimal surface area possible for disordered cellular structures.
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Vibrational modes identify soft spots in a sheared disordered packing.
We analyze low-frequency vibrational modes in a two-dimensional, zero-temperature, quasistatically sheared model glass to identify a population of structural "soft spots" where particle…
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Strain localization in a shear transformation zone model for amorphous solids.
TLDR
A criterion is derived that determines which materials exhibit shear bands based on the initial conditions alone, and it is shown that the shear band width is not set by an inherent diffusion length scale but instead by a dynamical scale that depends on the imposed strain rate.
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The Syncytial Drosophila Embryo as a Mechanically Excitable Medium
TLDR
It is found that the dependence of wavefront speed on cycle number is most naturally explained by mechanical signaling, and that the entire process suggests a scenario in which biochemical and mechanical signaling are coupled.
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Aggregation and segregation of confined active particles.
TLDR
A mixture of bidisperse disks segregates in the absence of any adhesion, identifying a new mechanism that could contribute to cell sorting in embryonic development.
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Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo.
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Automated, contour-based tracking and analysis of cell behaviour over long time scales in environments of varying complexity and cell density
TLDR
An algorithm for tracking large numbers of cells for long time periods and a set of physics-based metrics that quantify differences in cell trajectories are introduced, including an unanticipated difference between two ‘control’ substrates.
View on Royal Society
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