• Publications
  • Influence
A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory
Cloninger (Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science 1987: 236: 410–416) proposed three basic personality dimensions for temperament: novelty seeking, harm avoidance, andExpand
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Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
Type II Rothmund-Thomson syndrome (Type II RTS) is a rare autosomal recessive genetic disorder characterized by a congenital skin rash, birth defects of the skeleton, genomic instability and cancerExpand
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Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression
To provide a more comprehensive understanding of the genes and evolutionary forces driving colorectal cancer (CRC) progression, we performed Sleeping Beauty (SB) transposon mutagenesis screens inExpand
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The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions
Soluble Escherichia coli-derived recombinant human stem cell factor (rhSCF) forms a non-covalently associated dimer. We have determined a dimer association constant (Ka) of 2-4 × 108 M−1, usingExpand
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Single–Cell Light Scatter as a Probe of Refractile Body Formation in Recombinant Escherichia Coli
Accumulation of foreign proteins as inclusion bodies in Escherichia coli was investigated using single–cell light scatter measurements from flow cytometry. Significant increases in forward–angleExpand
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Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression
Significance Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Despite extensive cancer genome-sequencing efforts, there is still an incomplete understanding of theExpand
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SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers
We have integrated SB data from primary tumor models into an analysis and reporting framework, Sleeping Beauty Cancer Driver DataBase (SBCDDB, http://sbcddb.org) that couples statistical tests with spatial information to provide context behind decisions identifying cancer driver genes. Expand
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Specificity of Hpa II and Hae III DNA methylases.
The methylases M.HaeIII and M.HpaII recognize the tetranucleotide sequences [Formula: see text] and [Formula: see text] respectively, in DNA, and transfer a methyl group from S-adenosylmethionine toExpand
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Control of misincorporation of de novo synthesized norleucine into recombinant interleukin-2 in E. coli.
  • L. Tsai, H. Lu, +6 authors M. Mann
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 31 October 1988
Interleukin-2 produced from a recombinant E. coli was found to contain as much as 19% norleucine in place of methionine in a minimal medium fermentation. Medium supplementation experiments and use ofExpand
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Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease.
The activity of human phenylethanolamine N-methyltransferase (PNMT) is reduced in the neurons of those cells in many subcortical areas of the brain that are known to undergo neurodegeneration inExpand
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