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Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.
TLDR
Prophylaxis with recombinant factor VIII can prevent joint damage and decrease the frequency of joint and other hemorrhages in young boys with severe hemophilia A.
Low-Dose Tissue Plasminogen Activator Thrombolysis in Children
TLDR
TPA in very low doses appears to be safe and effective for thrombolysis of acute thromboses in most children, given appropriate patient selection.
Definitions in hemophilia: communication from the SSC of the ISTH
TLDR
The once-in-a-lifetime opportunity to assess the importance of knowing the carrier and removal status of canine coronavirus in the context of thrombosis and haemostasis is presented.
A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.
TLDR
Patients treated with plasma-derived factor VIII containing von Willebrand factor had a lower incidence of inhibitors than those treated with recombinant factor VIII, and this association did not change in multivariable analysis.
Impact of Inherited Thrombophilia on Venous Thromboembolism in Children: A Systematic Review and Meta-Analysis of Observational Studies
TLDR
The present meta-analysis indicates that detection of IT is clinically meaningful in children with, or at risk for, VTE and underscores the importance of pediatric thrombophilia screening programs.
How I treat venous thrombosis in children.
TLDR
Evidence-based medicine for pediatric thrombosis is in its infancy and antithrombotic therapy for infants and children was largely based on individual empiric experience, small case series, or was extrapolation from adult recommendations.
Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors
TLDR
It is imperative that future collaborative pediatric prospective cohort studies and trials assess as key objectives and outcomes the incidence, severity, prognostic indicators, and health impact of post-thrombotic syndrome, using validated measures.
von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) 1
TLDR
This document summarizes needs for further research in VWF, VWD and bleeding disorders, including clinical research to obtain more objective information about bleeding symptoms, advancements in diagnostic and therapeutic tools, and enhancement in the education and training of clinicians and scientists in bleeding and thrombotic disorders.
Phase 3 study of recombinant factor IX Fc fusion protein in hemophilia B.
TLDR
Prophylactic rFIXFc, administered every 1 to 2 weeks, resulted in low annualized bleeding rates in patients with hemophilia B, mostly consistent with those expected in the general population of patients withhemophilia.
Impact of Thrombophilia on Risk of Arterial Ischemic Stroke or Cerebral Sinovenous Thrombosis in Neonates and Children: A Systematic Review and Meta-Analysis of Observational Studies
TLDR
It is indicated that thrombophilias serve as risk factors for incident stroke through a meta-analysis of published observational studies and no significant heterogeneity was discerned across studies, and no publication bias was detected.
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