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A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
TLDR
Among patients receiving clopidogrel following acute myocardial infarction, concomitant therapy with proton pump inhibitors other than pantoprazole was associated with a loss of the beneficial effects of clopIDogrel and an increased risk of reinfarction. Expand
Atrial fibrillation in patients with cryptogenic stroke.
TLDR
Noninvasive ambulatory ECG monitoring for a target of 30 days significantly improved the detection of atrial fibrillation by a factor of more than five and nearly doubled the rate of anticoagulant treatment, as compared with the standard practice of short-duration ECG Monitoring. Expand
Harassment and Discrimination in Medical Training: A Systematic Review and Meta-Analysis
TLDR
This review demonstrates the surprisingly high prevalence of harassment and discrimination among medical trainees that has not declined over time and recommends both drafting policies and promoting cultural change within academic institutions to prevent future abuse. Expand
A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use.
TLDR
The use of statistical hypothesis testing, standardized differences, box plots, non-parametric density estimates, and quantile-quantile plots to assess residual confounding that remained after stratification or matching on the propensity score varied from 15 to 24 per cent across the different propensity score methods. Expand
Effectiveness of Virtual Reality Using Wii Gaming Technology in Stroke Rehabilitation: A Pilot Randomized Clinical Trial and Proof of Principle
TLDR
VRWii gaming technology represents a safe, feasible, and potentially effective alternative to facilitate rehabilitation therapy and promote motor recovery after stroke. Expand
Drug-drug interactions among elderly patients hospitalized for drug toxicity.
TLDR
Many hospital admissions of elderly patients for drug toxicity occur after administration of a drug known to cause drug-drug interactions, and many of these interactions could have been avoided. Expand
Chronic dialysis and death among survivors of acute kidney injury requiring dialysis.
TLDR
Acute kidney injury necessitating in-hospital dialysis was associated with an increased risk of chronic dialysis but not all-cause mortality, and the primary end point was the need for chronicdialysis. Expand
Opioid dose and drug-related mortality in patients with nonmalignant pain.
TLDR
Among patients receiving opioids for nonmalignant pain, the daily dose is strongly associated with opioid-related mortality, particularly at doses exceeding thresholds recommended in recent clinical guidelines. Expand
Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
TLDR
Opioid-related deaths in Ontario have increased markedly since 1991, and a significant portion of the increase was associated with the addition of long-acting oxycodone to the provincial drug formulary. Expand
Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis
TLDR
The protective association between statins and sepsis persisted in high-risk subgroups, including patients with diabetes mellitus, chronic renal failure, or a history of infections, who survived for at least 3 months after discharge. Expand
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