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Intermittent hypoxia induces early functional cardiovascular remodeling in mice.
RATIONALE Intermittent hypoxia, a hallmark of sleep apnea, is a major factor for hypertension and impaired vasoreactivity. OBJECTIVES To examine the temporal occurrence of these two outcomes inExpand
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The nocebo effect of drugs
While the placebo effect has been studied for a long time, much less is known about its negative counterpart, named the nocebo effect. However, it may be of particular importance because of itsExpand
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Critères pharmacologiques d'un médicament pour la substitution de la pharmacodépendance aux opiacés
Resume Nous proposons une definition actualisee des caracteristiques pharmacologiques minimales d’un medicament pouvant etre prescrit dans le traitement de la pharmacodependance aux opiaces. CesExpand
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Benzodiazepine‐Like Hypnotics and the Associated Risk of Road Traffic Accidents
The aim of the study was to investigate the association between the use of benzodiazepine or benzodiazepine‐like hypnotics and the risk of road traffic accidents. Data from three French nationalExpand
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Determination of buprenorphine and norbuprenorphine in urine and hair by gas chromatography-mass spectrometry.
Buprenorphine, which is used in France as a substitution drug for opioid addiction, is widely abused, and several fatal cases have been reported. In order to confirm a recent intoxication or toExpand
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Dextromethorphan and dextrorphan in rats: Common antitussives — Different behavioural profiles
Summary— Dextromethorphan (DM), a widely used and well‐tolerated centrally acting antitussive, has been tested in several clinical trials for its antiepileptic and neuroprotective properties.Expand
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Patterns and profiles of methylphenidate use both in children and adults
The aim of the present study was to characterize patterns of use of methylphenidate (MPH), a prescription stimulant medication recommended in the treatment of attention deficit hyperactivity disorderExpand
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[First meeting of the French CEIP (centres d'évaluation et d'information sur la pharmacodépendance). Assessment of the abuse and pharmacodependence potential during drug development].
The French system for the evaluation of abuse and dependence created in 1990 was definitely implemented in 1999 with the decree no99-249 making in particular mandatory the reporting of all seriousExpand
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Erythromelalgia and Mushroom Poisoning
Objective: To report the first European observations of erythromelalgia due to mushroom poisoning. Methods: Clinical features of erythromelalgia were observed in 7 cases seen over 3 years. AllExpand
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Discriminative stimulus properties of dextromethorphan in rats.
Male Sprague-Dawley rats were trained to discriminate dextromethorphan (DM, 30 mg/kg, ip) from saline using a standard two-lever, fixed ratio 10, food reinforcement procedure. The DM-salineExpand
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