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Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
TLDR
The methylation to acetylation switch correlates with the transcriptional activation of PcG target genes, both during ES cell differentiation and in MLL-AF9-transduced hematopoietic stem cells.
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CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
TLDR
A large-scale CRISPR-based screen to assess the function of ∼17,000 lncRNAs in seven different human cell lines showed that lncRNA function is highly cell type–specific, a finding that has important implications for their involvement in organismal development and disease.
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Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment
TLDR
It is concluded that blood-derived TAMs significantly infiltrate pre-treatment gliomas, to a degree that varies by glioma subtype and tumor compartment, and a novel signature that distinguishes TAMs by ontogeny in humangliomas is presented.
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Jarid1b targets genes regulating development and is involved in neural differentiation
TLDR
It is shown that the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for ESC self‐renewal, but essential for ESC differentiation along the neural lineage.
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Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation.
TLDR
The acetyltransferase PCAF is identified as a positive cofactor of the Hh-Gli signaling pathway, leading to proposed PCAF as a candidate therapeutic target for the treatment of patients with medulloblastomas and glioblastoma.
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The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3
TLDR
It is shown that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure, and genome-wide analysis of histone modifications suggests that Jarid 1b regulates mouse development by protecting developmental genes from inappropriate acquisition of active histone modification.
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Itch self-polyubiquitylation occurs through lysine-63 linkages.
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Itch: a HECT-type E3 ligase regulating immunity, skin and cancer
TLDR
This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability.
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
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The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
TLDR
It is demonstrated that N4BP1 functions as a negative regulator of Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity and inhibition of c-Jun and p63 polyubiquitylation by Itch.
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