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Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial
TLDR
Considering the limitations of an open-label study, adalimumab alone or in combination with standard DMARDs appeared to be well tolerated and effective in 6610 difficult-to-treat patients with active RA treated in clinical practice.
Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed.
TLDR
Among patients with RA for whom previous DMARD treatment had failed, adalimumab monotherapy achieved significant, rapid, and sustained improvements in disease activity and improved physical function and was safe and well tolerated.
The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood
TLDR
The results of experiments aimed at isolating MSC from UCB, BM and UCM using different methods of isolation and various culture media exclude UCB from the list of MSC sources for clinical use and propose instead UCM as a rich, non‐invasive and abundant source of M SC.
Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
TLDR
The question of cell death causality in OA progression is addressed, as well as the molecular pathways leading to cell death in response to the following inducers: Fas, Interleukin-1 β (IL-1β), Tumor Necrosis factor-α (TNF-α), leptin, nitric oxide (NO) donors, and mechanical stresses.
EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Prevalence of inflammation in osteoarthritis
TLDR
US can detect synovial inflammation and effusion in painful knee OA, which correlate significantly with knee synovitis, effusion, and clinical parameters suggestive of an inflammatory “flare”.
Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
TLDR
Longitudinal evaluation of this OA cohort demonstrated significant progression to joint replacement, in addition to severity of radiographic damage and pain, US-detected effusion was a predictor of subsequent joint replacement.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment
TLDR
Serum MMP-3 serum levels are increased in inflammatory rheumatic diseases characterised by joint synovitis, such as RA, polymyalgia Rheumatica, psoriatic arthritis, and acute crystal arthritis—that is, whether the diseases are acute or chronic, erosive or not.
Chondrocyte dedifferentiation and osteoarthritis (OA).
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