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Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.
The RAG1 recombinase, which participates in DNA manipulation during rearrangement of antigen receptor genes in developing immune cells, possesses ubiquitin ligase activity. The nuclear transportExpand
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Benralizumab for PDGFRA‐Negative Hypereosinophilic Syndrome
Background Hypereosinophilic syndrome is a group of diseases defined by marked eosinophilia in blood or tissue and eosinophil‐related clinical manifestations. Benralizumab is a monoclonal antibodyExpand
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Development of Norwalk Virus-Specific Monoclonal Antibodies with Therapeutic Potential for the Treatment of Norwalk Virus Gastroenteritis
ABSTRACT Passive immunoprophylaxis or immunotherapy with norovirus-neutralizing monoclonal antibodies (MAbs) could be a useful treatment for high-risk populations, including infants and youngExpand
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Clinical and Biological Markers in Hypereosinophilic Syndromes
Hypereosinophilic syndromes (HES) are rare, heterogeneous syndromes characterized by markedly elevated eosinophil counts in the blood and/or tissue and evidence of eosinophil-associated pathology.Expand
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Cross-neutralizing human anti-poliovirus antibodies bind the recognition site for cellular receptor
Significance This study demonstrated that cross-neutralizing anti-poliovirus antibodies bind the site on poliovirus capsid surface that significantly overlaps the binding site of the cellularExpand
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Chimpanzee-Human Monoclonal Antibodies for Treatment of Chronic Poliovirus Excretors and Emergency Postexposure Prophylaxis
ABSTRACT Six poliovirus-neutralizing Fabs were recovered from a combinatorial Fab phage display library constructed from bone marrow-derived lymphocytes of immunized chimpanzees. The chimericExpand
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Dexpramipexole As a Steroid-Sparing Agent in Hypereosinophilic Syndromes (HES): An Open-Label Proof-of-Concept Study
Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders characterized by peripheral eosinophilia and eosinophil-related end organ damage. Whereas most patients respond to steroidExpand
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Tumor size as prognostic factor in osteosarcomas.
9061 Background: Multidisciplinary treatment of osteosarcoma has achieved overall survival greater than 70%. Several prognostic factors have been described. In our country it is frequent to diagnoseExpand