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Embryonic Lethality in Mice Lacking the Nuclear Factor of Activated T Cells 5 Protein Due to Impaired Cardiac Development and Function
TLDR
It is demonstrated that cardiac failure is most likely responsible for the peripheral edema and death of NFAT5−/− embryos at E14.5 days, and an essential role ofNFAT5 in cardiac development and Ca2+ signaling is demonstrated.
Ubiquitination of p53 at Multiple Sites in the DNA-Binding Domain
TLDR
Using a method involving in vitro proteolytic cleavage at specific sites after ubiquitination, it is found that p53 was ubiquitinated at the NH2-terminal portion of the protein.
Ubiquitination of p 53 at Multiple Sites in the DNA-Binding Domain
TLDR
Evidence is provided that in addition to the COOH-terminal residues, p53 may also be ubiquitinated at sites in the DNA-binding domain, which would provide evidence that ubiquitination seems to serve more complex function than simply targeting p53 to the proteasome.
Title Embryonic lethality in mice lacking the nuclear factor of activated t cells 5 protein due to impaired cardiac development and function
TLDR
It is demonstrated that cardiac failure is most likely responsible for the peripheral edema and death of NFAT5 embryos at E14.5 days, and an essential role ofNFAT5 in cardiac development and Ca signaling is demonstrated.