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A study of the scope and regioselectivity of the ruthenium-catalyzed [3 + 2]-cycloaddition of azides with internal alkynes.
TLDR
Propargyl alcohols and propargyl amines were found to react with azides to afford single regioisomeric products, leading to 1,4,5-trisubstituted-1,2,3-triazoles.
Total synthesis of the unusual monoterpenoid indole alkaloid (±)-alstilobanine A.
TLDR
The first approach to these alkaloids is described, culminating in a convergent total synthesis of racemic alstilobanine A (3), which lacks the bridging oxepane ring found in 1 and 2, in the same plant.
Synthesis, Characterization, and Computational Modeling of N-(1-Ethoxyvinyl)pyridinium Triflates, an Unusual Class of Pyridinium Salts
TLDR
A preliminary synthesis and detailed structural analysis of several N-(1-ethoxyvinyl)pyridinium triflates is reported, an unusual class of pyrid inium salts with potentially broad use as a reagent in organic synthesis.
Efficient methodology for alkylation of vinylnitroso compounds with carbon nucleophiles.
A diverse array of nitrosoalkenes derived from both acyclic and cyclic ketones, as well as aldehydes, via the Denmark protocol using alpha-chloro-O-TBS-oximes can be trapped efficiently in situ by a
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
TLDR
Differences in Eg5-microtubule binding between malignant and normal blood cells may be exploited to treat multiple myeloma and indicate that unbiased chemical biology approaches can identify therapeutic strategies unanticipated by prior knowledge of protein targets.
Synthesis of phthalan and phenethylamine derivatives via addition of alcohols to rhodium(II)-azavinyl carbenoids
Abstract 1-Sulfonyl-1,2,3-triazoles undergo inter- and intramolecular 1,3-OH insertion with rhodium(II)-azavinyl carbenoid intermediates upon treatment with a rhodium(II) catalyst. Products of this
Total syntheses of the monoterpene indole alkaloids (±)-alstilobanine A and E and (±)-angustilodine.
TLDR
A synthetic strategy has been developed culminating in stereoselective total syntheses of the small class of unusual monoterpenoid indole alkaloids exemplified by alstilobanines A and E and angustilodine, leading to the three alkaloid in racemic form.
A mild, efficient method for the oxidation of α-diazo-β-hydroxyesters to α-diazo-β-ketoesters
Abstract A wide variety of α-diazo-β-ketoesters can be prepared in good overall yields via a two-step sequence involving addition of ethyl lithiodiazoacetate to aliphatic, aromatic, and conjugated
An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds.
A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both
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