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Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3.
First evidence is provided that humans homozygous for the PER3 5/5 allele are particularly sensitive to blue-enriched light, as indexed by the suppression of endogenous melatonin and waking theta activity. Expand
Pushing the Limits: Chronotype and Time of Day Modulate Working Memory-Dependent Cerebral Activity
The hypothesis that higher task complexity leads to a chronotype-dependent increase in thalamic and frontal brain activity, permitting stabilization of working memory performance across the day is supported. Expand
Effects of Artificial Dawn and Morning Blue Light on Daytime Cognitive Performance, Well-being, Cortisol and Melatonin Levels
Exposure to an artificial morning dawn simulation light improves subjective well-being, mood, and cognitive performance, as compared with DL and BL, with minimal impact on circadian phase. Expand
Sleep EEG alterations: effects of pulsed magnetic fields versus pulse‐modulated radio frequency electromagnetic fields
It is demonstrated that both pulse‐modulated radio frequency and pulsed magnetic fields affect brain physiology, and the presence of significant frequency components above 20 Hz are not fundamental for these effects to occur. Expand
Sleep ability mediates individual differences in the vulnerability to sleep loss: Evidence from a PER3 polymorphism
The data suggest that the group with greater attentional performance impairment due to sleep deprivation (PER3(5/5) carriers) is superior at initiating sleep over the 24-h cycle and this higher sleep ability may mirror a faster sleep pressure build-up between the multiple sleep opportunities and thus a greater flexibility in sleep initiation. Expand
Dawn simulation light impacts on different cognitive domains under sleep restriction
It is indicated that short exposure to artificial morning light may significantly enhance cognitive performance in a domain-specific manner under conditions of mild SR. Expand
Insights into Behavioral Vulnerability to Differential Sleep Pressure and Circadian Phase from a Functional ADA Polymorphism
These data confirm the assumption that interindividual differences regarding the effect of sleep manipulation highly depend on the cognitive task and circadian phase and thus emphasize the necessity of a multimethodological approach and indicate that napping might be suitable to counteract endogenously heightened sleep pressure depending on the neurobehavioral domain. Expand
In human beings, homeostatic and circadian sleep-wake regulatory processes are working together for the maintenance of sleep and wakefulness at appropriate times within the 24-hour light-dark cycle.Expand
Light modulation of human sleep depends on a polymorphism in the clock gene Period3
The data indicate that humans homozygous for the PER3(5/5) allele are more sensitive to NIF light effects, as indexed by specific changes in sleep EEG activity, which may depend on a clock gene polymorphism involved in sleep-wake regulation. Expand
Prevalence and management of chronic insomnia in Swiss primary care: Cross‐sectional data from the “Sentinella” practice‐based research network
Reducing the burden of insomnia depends on disseminating knowledge about and access to CBT‐I, and encouraging PCPs to discuss it with and offer it as a first‐line treatment to patients with chronic insomnia. Expand