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Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
Cyclic adenosine monophosphate (cAMP)-dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensoryExpand
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Activation of Receptor-operated Cation Channels via P Not P Purinoceptors in Human Platelets (*)
We have investigated the purinoceptor subtypes responsible for calcium signaling in human platelets, which previous studies have shown to involve both Ca influx via receptor-operated cation channelsExpand
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Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte
The molecular identity of platelet Ca2+ entry pathways is controversial. Furthermore, the extent to which Ca2+‐permeable ion channels are functional in these tiny, anucleate cells is difficult toExpand
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A role for membrane potential in regulating GPCRs?
G-protein-coupled receptors (GPCRs) have ubiquitous roles in transducing extracellular signals into cellular responses. Therefore, the concept that members of this superfamily of surface proteins areExpand
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Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart
Aim:  Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification.
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Three cation influx currents activated by purinergic receptor stimulation in rat megakaryocytes.
1. Simultaneous patch clamp and fura‐2 fluorescence measurements were used to study ATP‐evoked membrane currents and intracellular [Ca2+] ([Ca2+]i) changes in rat megakaryocytes. 2. At negativeExpand
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Emerging roles for P2X1 receptors in platelet activation
TLDR
The platelet surface membrane possesses three P2 receptors activated by extracellular adenosine nucleotides; one member of the ionotropic receptor family (P2X1) and two members of the G-protein-coupled receptor family. Expand
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Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
Background— Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells orExpand
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Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP.
Simultaneous measurements of [Ca2+]i and light transmission were used to examine the relationship between P2X1 receptor activation and functional platelet responses. The P2X1 agonist alpha,beta-MeATPExpand
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Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model
The difficulty of conducting electrophysiologic recordings from the platelet has restricted investigations into the role of ion channels in thrombosis and hemostasis. We now demonstrate that theExpand
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