• Publications
  • Influence
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
Cyclic adenosine monophosphate (cAMP)-dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensoryExpand
  • 527
  • 26
Activation of Receptor-operated Cation Channels via P Not P Purinoceptors in Human Platelets (*)
We have investigated the purinoceptor subtypes responsible for calcium signaling in human platelets, which previous studies have shown to involve both Ca influx via receptor-operated cation channelsExpand
  • 214
  • 10
Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte
The molecular identity of platelet Ca2+ entry pathways is controversial. Furthermore, the extent to which Ca2+‐permeable ion channels are functional in these tiny, anucleate cells is difficult toExpand
  • 60
  • 7
A role for membrane potential in regulating GPCRs?
G-protein-coupled receptors (GPCRs) have ubiquitous roles in transducing extracellular signals into cellular responses. Therefore, the concept that members of this superfamily of surface proteins areExpand
  • 78
  • 5
Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart
Aim:  Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification.
  • 46
  • 5
Three cation influx currents activated by purinergic receptor stimulation in rat megakaryocytes.
1. Simultaneous patch clamp and fura‐2 fluorescence measurements were used to study ATP‐evoked membrane currents and intracellular [Ca2+] ([Ca2+]i) changes in rat megakaryocytes. 2. At negativeExpand
  • 58
  • 4
Emerging roles for P2X1 receptors in platelet activation
The platelet surface membrane possesses three P2 receptors activated by extracellular adenosine nucleotides; one member of the ionotropic receptor family (P2X1) and two members of the G-protein-coupled receptor family. Expand
  • 74
  • 4
Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
Background— Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells orExpand
  • 68
  • 4
  • PDF
Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP.
Simultaneous measurements of [Ca2+]i and light transmission were used to examine the relationship between P2X1 receptor activation and functional platelet responses. The P2X1 agonist alpha,beta-MeATPExpand
  • 71
  • 4
Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model
The difficulty of conducting electrophysiologic recordings from the platelet has restricted investigations into the role of ion channels in thrombosis and hemostasis. We now demonstrate that theExpand
  • 65
  • 4
  • PDF