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Bile acids are steroid carboxylic acids containing 22–28 carbon atoms (Haslewood, 1967, 1978). The common naturally occurring bile acids are saturated C24 acids. Bile acids are found only in… (More)
The effect of inhibition of polyamine biosynthesis byα-difluoromethylornithine (DFMO) on the growth of two murine transplantable tumours was studied. Female CBA mice were implanted with either the… (More)
The polyamines (putrescine, spermidine, spermine) and the key enzyme controlling their synthesis (ornithine decarboxylase, ODC) are considered important for many adaptive growth responses. In most… (More)
The enzyme diamine oxidase (DAO) is almost exclusively confined to the intestinal mucosa where it plays important roles in the metabolism of the poly-amines and the degradation of histamine… (More)
Objective: To examine the hypothesis that hepatic bile acid sulphation may be specifically impaired in the cholestatic liver disease, primary biliary cirrhosis (PBC), conceiveably leading to ongoing… (More)