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Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test
TLDR
This new system quantitatively simulated human absorption and would be beneficial for the prediction of human Fa values for BCS class II drugs. Expand
Optimized conditions of bio-mimetic artificial membrane permeation assay.
TLDR
Effects of pH and co-solvents on the bio-mimetic artificial membrane permeation assay were investigated to determine the optimal conditions for the prediction of oral absorption and the appropriate conditions for determining the permeability of poorly soluble compounds were examined. Expand
High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay
TLDR
The purpose of the present study was to improve the composition of the lipid solution used in parallel artificial membrane permeation assay for the precise prediction of oral absorption by changing the chain length of organic solvent. Expand
Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model.
TLDR
The BAMPA-PP-RF model was shown to be able to predict the total passive permeability more adequately than BAMpa alone. Expand
Prediction of human intestinal permeability using artificial membrane permeability.
TLDR
P(PAMPA-PP-RF) was found to be an adequate in vitro surrogate for P(eff) and the effect of the unstirred water layer was incorporated to the prediction scheme. Expand
Prediction of oral drug absorption in humans by theoretical passive absorption model.
TLDR
The TPAM was found to predict oral absorption from the chemical structure of drugs with adequate predictability for usage in drug discovery. Expand
Magnetite/Ilmenite–series Classification and Magnetic Susceptibility of the Mesozoic‐Cenozoic Batholiths in Peru
Abstract: Plutonic rocks of the Coastal Batholith of Peru were evaluated in terms of the granitoid-series classification using the bulk ferric/ferrous ratio from the literature and new measurementsExpand
Biopharmaceutics Classification by High Throughput Solubility Assay and PAMPA
TLDR
The result showed that HTSA could predict BCS class with a high success rate, and PAMPA could also be useful to predict the permeation of drugs. Expand
The effects of absorption enhancers on the pulmonary absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats.
TLDR
Pulmonary absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) with various surfactants and protease inhibitors were examined in rats and it was considered that permeation and enzymatic degradation were rate-determining steps in the pulmonary absorption of rhG- CSF after i.t. administration. Expand
Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) from Rat Nasal Mucosa
TLDR
It is indicated that nasal administration of rhG-CSF is an effective parenteral administration route and the addition of Laureth-9 further increased the pharmacological effects of this agent. Expand
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