A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients.
- G. Rossi, G. Bernini, F. Mantero
- Medicine, BiologyJournal of the American College of Cardiology
- 5 December 2006
Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.
- E. Arvat, M. Maccario, E. Ghigo
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 March 2001
Ghrelin, a natural ligand of GHS-receptor, exerts a strong stimulatory effect on GH secretion in humans, releasing more GH than GHRH and even more than a nonnatural GHS such as HEX, which possesses strong GH-releasing activity but also significantly stimulates PRL, ACTH, and cortisol secretion.
Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma
- F. Fernandes-Rosa, T. Williams, M. Zennaro
- Biology, MedicineHYPERTENSION
- 1 August 2014
Investigation of the prevalence of somatic mutations in aldosterone-producing adenomas in unselected patients with APA found that young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options.
Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement
- R. Garberoglio, C. Aliberti, M. Zingrillo
- MedicineJournal of Ultrasound
- 19 June 2015
Current guidelines do not recommend its routine use in clinical practice, suggesting its usefulness in some cases only, but over the last two decades, nonsurgical, minimally invasive, US-guided techniques have been proposed for the treatment of thyroid nodules.
The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index.
- G. Corneli, C. Di Somma, G. Aimaretti
- Medicine, BiologyEuropean Journal of Endocrinology
- 1 August 2005
The GHRH-ARG test is a reliable tool for the diagnosis of adult GH deficiency in lean, overweight and obese patients, provided that specific BMI-related cut-off limits are assumed.
Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor
- E. Ghigo, F. Broglio, E. Arvat, M. Maccario, M. Papotti, G. Muccioli
- BiologyClinical Endocrinology
- 1 January 2005
The original and fascinating story of ghrelin, as well as its potential pathophysiological implications in endocrinology and internal medicine, is not definitively cancelled by these data as GHS‐R1a null aged mice show significant alterations in body composition and growth, in glucose metabolism, cardiac function and contextual memory.
Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study.
- R. Pasquali, B. Ambrosi, R. Vettor
- MedicineJournal of Clinical Endocrinology and Metabolism
- 2002
The data suggest that, at least in women, abdominal fat distribution may partially counteract the progressively greater suppressibility of the HPA axis that would be expected according to increasing BMI.
Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma
- G. Rossi, A. Belfiore, F. Mantero
- Medicine, BiologyHYPERTENSION
- 1 August 2007
Both the CAPT and the SAL are safe and moderately accurate for excluding APA; at a sodium intake >7.6 g per day, the SAL offers no advantage over the easier-to-perform CAPT.
Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans.
- F. Broglio, C. Gottero, E. Ghigo
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 September 2003
Findings support the hypothesis that ghrelin exerts modulatory action of insulin secretion and glucose metabolism in humans and raises basal glucose levels and enhances the hyperglycemic effect of ARG but not that of OGTT.
Comparison of confirmatory tests for the diagnosis of primary aldosteronism.
- P. Mulatero, A. Milan, M. Maccario
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 July 2006
This study demonstrates that the iv SLT is a reasonably good alternative to the more expensive and complex FST for the diagnosis of PA after a positive screening test.
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