• Publications
  • Influence
A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients.
TLDR
In newly diagnosed hypertensive patients referred to hypertension centers, the prevalence of APA is high (4.8%) and the availability of AVS is essential for an accurate identification of the adrenocortical pathologies underlying PA. Expand
Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.
TLDR
Ghrelin, a natural ligand of GHS-receptor, exerts a strong stimulatory effect on GH secretion in humans, releasing more GH than GHRH and even more than a nonnatural GHS such as HEX, which possesses strong GH-releasing activity but also significantly stimulates PRL, ACTH, and cortisol secretion. Expand
Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma
TLDR
Investigation of the prevalence of somatic mutations in aldosterone-producing adenomas in unselected patients with APA found that young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options. Expand
The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index.
TLDR
The GHRH-ARG test is a reliable tool for the diagnosis of adult GH deficiency in lean, overweight and obese patients, provided that specific BMI-related cut-off limits are assumed. Expand
Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement
TLDR
Current guidelines do not recommend its routine use in clinical practice, suggesting its usefulness in some cases only, but over the last two decades, nonsurgical, minimally invasive, US-guided techniques have been proposed for the treatment of thyroid nodules. Expand
Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans.
TLDR
Findings support the hypothesis that ghrelin exerts modulatory action of insulin secretion and glucose metabolism in humans and raises basal glucose levels and enhances the hyperglycemic effect of ARG but not that of OGTT. Expand
Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor
TLDR
The original and fascinating story of ghrelin, as well as its potential pathophysiological implications in endocrinology and internal medicine, is not definitively cancelled by these data as GHS‐R1a null aged mice show significant alterations in body composition and growth, in glucose metabolism, cardiac function and contextual memory. Expand
Comparison of confirmatory tests for the diagnosis of primary aldosteronism.
TLDR
This study demonstrates that the iv SLT is a reasonably good alternative to the more expensive and complex FST for the diagnosis of PA after a positive screening test. Expand
Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study.
TLDR
The data suggest that, at least in women, abdominal fat distribution may partially counteract the progressively greater suppressibility of the HPA axis that would be expected according to increasing BMI. Expand
Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas
TLDR
Somatic mutations are common in APAs that result in an increase in CYP11B2 gene expression and may account for the dysregulated aldosterone production in a subset of patients with sporadic primary aldosteronism. Expand
...
1
2
3
4
5
...