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Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
TLDR
It was found that fractions as well as kaurenoic acid and luteolin exhibit marked antinociceptive action in mice using acetic acid-induced writhing, more active than some well-known analgesic drugs, such as acetyl salicylic acid, acetaminophen, dipyrone and indomethacin. Expand
From popular use to pharmacological validation: a study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract.
TLDR
The aim of the present study was to further the understanding of the anti-nociceptive, anti-inflammatory and wound healing effects of ethanol extract obtained from the leaves and stems of Chenopodium ambrosioides in animal models of acute pain, inflammation and wound Healing. Expand
Capillariaisis (Trichurida, Trichinellidae, Capillaria hepatica) in the Brazilian Amazon: low pathogenicity, low infectivity and a novel mode of transmission
TLDR
The present study is the first one carried out in a native Amazonian population and indicates the presence of antibodies against C. hepatica in this population, and suggests that the transmission of the parasite occurs by the ingestion of embryonated eggs from human feces and/or carcasses of wild animals. Expand
Antinociceptive properties of the methanolic extract obtained from Ipomoea pes-caprae (L.) R. Br.
TLDR
The results indicated that both methanolic extract and two fractions exhibited considerable antinociceptive activity against two classical models of pain in mice, supporting the popular use of I. pes-caprae to treat dolorous processes. Expand
Antinociceptive activity of I3,II8-binaringenin, a biflavonoid present in plants of the guttiferae.
TLDR
It was found that 13,118-binaringenin (GB-1a), a biflavonoid isolated from Clusia columnaris and present in several plants of the family Guttiferae, exhibits potent and dose-related antinociceptive action in both experimental models, with ID50 values of 22 mumol/kg against the writhing test and 28 mumol/. Expand
Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
TLDR
The synthesis of new cyclic imides obtained by reaction with aminophenazone and different anhydrides with further cyclization with acetic acid under reflux indicated that compound 3 exerts potent analgesic activity in mice, being more active than some reference drugs. Expand
Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
TLDR
The phytochemical analysis indicated that the chemical composition of the plant grown in Brazil is similar to that grown in other countries, which confirm and justify the popular use of this plant for the treatment of dolorous processes. Expand
Interstitial dendritic cells of the heart harbor Trypanosoma cruzi antigens in experimentally infected dogs: importance for the pathogenesis of chagasic myocarditis.
TLDR
Findings suggest that IDCs, probably by presenting T. cruzi antigens to immune-competent cells, play an important role in the pathogenesis of Chagas disease. Expand
The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: evidence for the involvement of adrenergic, dopaminergic and serotonergic systems.
TLDR
The results indicate that the antidepressant-like effect of H. brasiliense (and podoandin) is dependent on the serotonergic, noradrenergic and dopaminergic systems, but not on the GABAergic, opioid and oxidonitrergic systems. Expand
Further antinociceptive properties of extracts and phenolic compounds from Plinia glomerata (Myrtaceae) leaves.
TLDR
The results confirm previous studies carried out by the research group regarding the antinociceptive properties of P. glomerata, stimulating other studies on mechanism of action as well as the determination of additional active principles in this plant. Expand
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