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Crucial role of neutrophils in the development of mechanical inflammatory hypernociception
During the inflammatory process, the migrating neutrophils participate in the cascade of events leading to mechanical hypernociception, at least by mediating the release of direct‐acting hypernOCiceptive mediators, such as PGE2.
NF‐κB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury
Inhibition of NF‐κB prevents tissue injury and lethality, and this was associated with inhibition of TNF‐α production and decrease in neutrophil recruitment, an effect likely to be secondary to the inhibition of systemic T NF‐α levels.
Absence of gut microbiota influences lipopolysaccharide-induced behavioral changes in mice
Increased serum levels of CCL11/eotaxin in schizophrenia
Neutrophils recruited by CXCR1/2 signalling mediate post‐incisional pain
The function of neutrophils in the genesis of post‐incisional pain in an experimental model of post-surgical pain is addressed in a study on neutrophil migration and activation triggered by CXCL1‐CXCR1/2 signalling.
Traffic of leukocytes in the central nervous system is associated with chemokine up-regulation in a severe model of herpes simplex encephalitis: An intravital microscopy study
Tumor necrosis factor alpha (TNF-α) levels in the brain and cerebrospinal fluid after meningitis induced by Streptococcus pneumoniae
Platelet‐activating factor receptor plays a role in the pathogenesis of graft‐versus‐host disease by regulating leukocyte recruitment, tissue injury, and lethality
PAFR on donor leukocytes plays a critical role in GVHD by mediating leukocyte influx and cytokine production in target tissues and may potentially be useful in the treatment of GV HD in bone marrow‐transplanted patients.
Cytokines and neutrophils as important mediators of platelet‐activating factor‐induced kinin B1 receptor expression
- E. Fernandes, G. F. Passos, J. Calixto
- Biology, MedicineBritish journal of pharmacology
- 1 September 2005
In conclusion, the activation of the TNF‐α/neutrophil axis by PAF seems to be sufficient for B1 receptor mRNA production, however, the T NF‐α /neutrophic axis is also necessary for IL‐1β production.
Adapting to environmental stresses: the role of the microbiota in controlling innate immunity and behavioral responses
- C. T. Fagundes, F. Amaral, A. Teixeira, Danielle G Souza, M. M. Teixeira
- BiologyImmunological reviews
- 1 January 2012
It is shown that the transition between a non‐colonized and a colonized state is associated with modification on the pattern of host inflammatory and behavioral responsiveness, which leads to significant alteration in host behavior to environmental threats.