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Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands.
The findings suggest at least two roles for fkh in formation of the embryonic salivary glands: an early role in promoting survival of the secretory cells, and a later role in secretory cell invagination, specifically in the constriction of the apical surface membrane.
Epithelial Tube Morphology Is Determined by the Polarized Growth and Delivery of Apical Membrane
Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia.
It is proposed that hkb dictates the initial site of internalization, the order in which invagination progresses and, consequently, the final shape of the organ, and fas is required for hkb-dependent signaling events that coordinate internalization.
The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species
It is concluded that the Ad5 L4 100-kDa protein is necessary for efficient initiation of translation of viral late mRNA species during the late phase of infection.
Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.
Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase.
pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland.
The secretory defects in ps mutants provide a potential mechanism for the loss of motor function observed in POMA patients, and are consistent with a role in splicing.
Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape
In vitro studies of lumen formation using cultured cells grown as cysts in three-dimensional matrices revealed an essential role for the Rho family GTPase Cdc42 in de novo lumenformation, suggesting a crucial role for Pak kinases in tube and lumen morphogenesis; however, the mechanism by which Paks act is not known.
Rac function in epithelial tube morphogenesis.
Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin
The studies reveal a novel mechanism for controlling salivary gland lumen size, namely through Rho1-dependent actin polymerization and distribution and downregulation of apical phosphorylated Moesin.