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Serotonin targets inhibitory synapses to induce modulation of network functions
TLDR
It is demonstrated that 5-HT1AR modulation primarily affects inhibition through glycinergic synapses, which stabilizes the rhythmicity of breathing during opiate medication of pain and helps to overcome opiate-induced respiratory depression. Expand
Modeling the ponto-medullary respiratory network
TLDR
The model and experimental data described support the concept that during eupnea the respiration-related pontine structures control the medullary network mechanisms for respiratory phase transitions, suppress the intrinsic pacemaker-driven oscillations in the pre-BotC and provide inspiration-inhibitory and expiration-facilitatory reflexes which are independent of the pulmonary Hering-Breuer reflex but operate through the same medullARY phase switching circuits. Expand
Pontine respiratory activity involved in inspiratory/expiratory phase transition
TLDR
Existing models for ponto-medullary interaction that may be involved in the control of inspiratory duration and IE phase transition are discussed and a number of pontine-Medullary interactions not considered before are proposed. Expand
Activation of Orexin B receptors in the pontine Kölliker-Fuse nucleus modulates pre-inspiratory hypoglossal motor activity in rat
TLDR
It is concluded that OXB release in the KF has strong implications in the state-dependent control of upper airway patency under physiological and pathophysiological conditions. Expand
Learning to breathe: control of the inspiratory–expiratory phase transition shifts from sensory‐ to central‐dominated during postnatal development in rats
TLDR
It is concluded that as postnatal maturation advances, synaptic mechanisms involving NMDA receptors in the KFn can override the vagally evoked IOS after ‘training’ using repetitive stimulation trials. Expand
Development of adaptive behaviour of the respiratory network: implications for the pontine Kölliker-Fuse nucleus
TLDR
It is proposed that a subpopulation of neurones within the Kolliker-Fuse nucleus represent command neurones for sensory processing which are capable of initiating adaptive behaviour in the respiratory network. Expand
Learning to breathe: Habituation of Hering–Breuer inflation reflex emerges with postnatal brainstem maturation
TLDR
The study shows that neonates stereotypically exhibit HBR stimulus-dependent prolongation of expiration while juvenile preparations showed significant habituation of HBR following repetitive stimulation, which explains the weak contribution and high activation threshold of H BR in the regulation of eupnea. Expand
Postnatal emergence of synaptic plasticity associated with dynamic adaptation of the respiratory motor pattern
TLDR
It is proposed that dependent on developmental changes in glutamatergic synaptic functions and its modulation by brain-derived neurotrophic factor, the CPG becomes permissive for short- and long-term plasticity associated with environmental, metabolic and behavioural adaptation of the breathing pattern. Expand
Developmental changes in brain‐derived neurotrophic factor‐mediated modulations of synaptic activities in the pontine Kölliker–Fuse nucleus of the rat
TLDR
The data suggest that KF neurones are subject to BDNF‐mediated fast synaptic modulation after completion of postnatal maturation, which may be important for network plasticity associated with the processing of afferent information. Expand
Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.
TLDR
It is concluded that CRS mediated AChE inhibition causes only transient central breathing disturbance, and apparently intrinsic brainstem mechanisms can compensate for cholinergic over activation. Expand
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