• Publications
  • Influence
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
  • M. Lyon
  • Biology, Medicine
  • Nature
  • 22 April 1961
Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyknotic. They interpreted thisExpand
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Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse.
Small eyes (Sey) is a semidominant, homozygous lethal mutation in the mouse (Roberts, 1967). It is allelic with SeyH, a radiation-induced homozygous prenatal lethal which has been mapped onExpand
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X-Chromosome inactivation: a repeat hypothesis
  • M. Lyon
  • Biology, Medicine
  • Cytogenetic and Genome Research
  • 1 July 1998
Recent work has shown that X-chromosome inactivation is brought about by Xist mRNA, which coats the inactive X-chromosome. This paper presents a hypothesis on the function of this RNA. It isExpand
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X-linked Gene for Testicular Feminization in the Mouse
The condition of testicular feminization in mice resembles that in man and other mammals. It is clearly X-linked. There is no evidence at present that the gene for testicular feminization is involvedExpand
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Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus
  • M. Lyon
  • Biology, Medicine
  • Cell
  • 1 June 1984
Transmission ratios of male mice heterozygous for various combinations of partial t-haplotypes provide evidence in support of a model for the genetic basis of ratio distortion, involving two or moreExpand
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Transmission ratio distortion in mice.
  • M. Lyon
  • Biology, Medicine
  • Annual review of genetics
  • 28 November 2003
The most studied example of transmission ratio distortion (TRD) in mice is that of the t-complex. This is a variant region of Chromosome 17 which exists as a polymorphism in wild mice. MalesExpand
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Sex chromatin and gene action in the mammalian X-chromosome.
  • M. Lyon
  • Biology, Medicine
  • American journal of human genetics
  • 1 May 1962
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Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.
Patterning of the vertebrate limb along the anterior-posterior axis is controlled by the zone of polarizing activity (ZPA) located at the posterior limb margin. One of the vertebrate Hh familyExpand
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Mouse chromosome atlas.
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Clonal analysis of X-chromosome inactivation and the origin of the germ line in the mouse embryo.
Cloning of cells from peri-implantation embryos by blastocyst injection was used to investigate the time of X-chromosome inactivation in that part of the ectoderm lineage giving rise to foetalExpand
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