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The evolutionary fate and consequences of duplicate genes.
Gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how frequently they evolveExpand
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Analysis of population genetic structure with RAPD markers
Recent advances in the application of the polymerase chain reaction make it possible to score individuals at a large number of loci. The RAPD (random amplified polymorphic DNA) method is one suchExpand
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Preservation of duplicate genes by complementary, degenerative mutations.
The origin of organismal complexity is generally thought to be tightly coupled to the evolution of new gene functions arising subsequent to gene duplication. Under the classical model for theExpand
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Estimation of pairwise relatedness with molecular markers.
Applications of quantitative genetics and conservation genetics often require measures of pairwise relationships between individuals, which, in the absence of known pedigree structure, can beExpand
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The analysis of population survey data on DNA sequence variation.
A technique is presented for the partitioning of nucleotide diversity into within- and between-population components for the case in which multiple populations have been surveyed for restriction-siteExpand
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THE GENETIC INTERPRETATION OF INBREEDING DEPRESSION AND OUTBREEDING DEPRESSION
  • M. Lynch
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 May 1991
Inbreeding with close relatives and outbreeding with members of distant populations can both result in deleterious shifts in the means of fitness‐related characters, most likely for very differentExpand
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The probability of duplicate gene preservation by subfunctionalization.
It has often been argued that gene-duplication events are most commonly followed by a mutational event that silences one member of the pair, while on rare occasions both members of the pair areExpand
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The similarity index and DNA fingerprinting.
  • M. Lynch
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 September 1990
DNA-fingerprint similarity is being used increasingly to make inferences about levels of genetic variation within and between natural populations. It is shown that the similarity index--the averageExpand
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PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION
Mildly deleterious mutation has been invoked as a leading explanation for a diverse array of observations in evolutionary genetics and molecular evolution and is thought to be a significant risk ofExpand
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EVOLUTION AND EXTINCTION IN A CHANGING ENVIRONMENT: A QUANTITATIVE‐GENETIC ANALYSIS
  • R. Bürger, M. Lynch
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 February 1995
Because of the ubiquity of genetic variation for quantitative traits, virtually all populations have some capacity to respond evolutionarily to selective challenges. However, natural selectionExpand
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