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Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
TLDR
The structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selectiveMitophagy.
A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
TLDR
The authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing and identifies an ERH interface required for interaction with an RNA binding protein.
Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila
TLDR
This research provides structural insights into the interactions between MLE dsRBDs and R2H1 and facilitates a deeper understanding of the mechanism by which MLE tandem ds RBDs play an indispensable role in specific recognition of roX and the assembly of the MSL-DCC in Drosophila dosage compensation.
Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.
  • M. Lv, Jia Gao, K. Ruan
  • Chemistry, Biology
    The journal of physical chemistry letters
  • 4 September 2020
TLDR
The first Tudor domain (Tudor1) of PHF20L1 recognizes (non)histone methylation to play versatile roles and the ligand-recognition mechanism remains unknown as a closed state revealed in the free-form structure, which shall entitle the discovery of small molecule inhibitors against the seemingly "undruggable" PHF 20L1 Tudor1.
Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.
TLDR
This research provides structural insights into the interactions between MLE dsRBDs and R2H1 and facilitates a deeper understanding of the mechanism by which MLE tandem ds RBDs play an indispensable role in specific recognition of roX and the assembly of the MSL-DCC in Drosophila dosage compensation.
Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.
Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
  • L. Zhu, Q. Hu, Q. Gong
  • Biology
    Biochemical and biophysical research…
  • 30 January 2020
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