Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests.
Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes
- Zheng Li, T. Hulderman, P. Simeonova
- Biology, MedicineEnvironmental Health Perspectives
- 4 December 2006
Aortic mitochondrial alterations by oxidative stress assays, including quantitative polymerase chain reaction of mitochondrial (mt) DNA and plaque formation by morphometric analysis in mice exposed to SWCNTs are evaluated, finding aortic mtDNA damage at 7, 28, and 60 days after exposure.
Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.
The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals and that research should focus primarily on effects on development of reproductive capability, on improved exposure assessment, and on the effects of mixtures.
Role of proinflammatory cytokines in acetaminophen hepatotoxicity.
- M. Blazka, J. Wilmer, S. Holladay, R. Wilson, M. Luster
- Biology, MedicineToxicology and Applied Pharmacology
- 1 July 1995
Data suggest that TNF-alpha and IL-1 alpha are released in response to APAP intoxication and are responsible for certain pathological manifestations of APAP-induced hepatotoxicity.
Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease
- K. Sriram, J. Matheson, S. Benkovic, D. Miller, M. Luster, J. O'Callaghan
- BiologyThe FASEB Journal
- 1 September 2002
The data indicate that the proinflammatory cytokine TNF‐α is an obligatory component of dopaminergic neurodegeneration, and implicate the participation of glial cells in MPTP‐induced neurotoxicity.
Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice.
Physiological role of tumor necrosis factor α in traumatic muscle injury
Data indicate that TNF‐α is involved in the recovery of muscle function after traumatic muscle injury, and this effect might be associated with modulation of muscle regulatory genes, including MyoD.
Development of a testing battery to assess chemical-induced immunotoxicity: National Toxicology Program's guidelines for immunotoxicity evaluation in mice.
Endotoxin‐induced cytokine gene expression and excretion in the liver
- M. Luster, D. Germolec, T. Yoshida, F. Kayama, M. Thompson
- Biology, MedicineHepatology
- 1 February 1994
This study uses semiquantitative polymerase chain reaction analysis and a recently developed liver slice model to examine the characteristics of cytokine profiles that occur in the liver, the main organ involved in endotoxemia, after lipopolysaccharide challenge and supports and extends previous findings.
Work, obesity, and occupational safety and health.
5 conceptual models of the interrelationship of work, obesity, and occupational safety and health are developed and the ethical, legal, and social issues related to fuller consideration of obesity's role in occupational health and safety are highlighted.