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Levodopa‐induced dyskinesias in Parkinson's disease: Clinical and pharmacological classification
TLDR
Clinical and pharmacological results indicate that LID in PD are a heterogeneous phenomenon difficult to explain on the basis of a single pathophysiological mechanism.
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Subthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysis.
TLDR
Results confirm and expand, at the cellular level, the paramount role of STN hyperactivity in the pathophysiology of parkinsonism and the therapeutic consequences for surgical treatment of Parkinson's disease are discussed.
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Motor complications associated with chronic levodopa therapy in Parkinson's disease.
TLDR
Patients with complex fluctuations are the least likely to improve with slow-release levodopa preparations, and drugs capable of providing a stable dopaminergic stimulation should be particularly useful for preventing the development of motor complications in patients not yet treated.
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Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders
TLDR
The increased dopaminergic tone created in the OBs of these patients could reflect a compensatory mechanism created by the early degeneration of other neurotransmitter systems and might contribute to the olfactory dysfunction exhibited by patients with neurodegenerative disorders.
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The Adult Macaque Spinal Cord Central Canal Zone Contains Proliferative Cells And Closely Resembles The Human
TLDR
It is found that the infant and adult human spinal cord contains ependymal cell types that resemble those present in the macaque, and a wide hypocellular layer formed by bundles of intermediate filaments surrounded the central canal both in the monkey and in the human.
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Serotonin 5‐HT1A receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys
TLDR
The results tend to support the possibility of an increased synthesis of 5‐HT1A receptors in brain regions with higher neuronal cell death, and may represent a compensatory event for the serotonergic dysfunction and associated mental disorders in neurodegenerative diseases such as Parkinson disease.
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Ultrastructure of the subventricular zone in Macaca fascicularis and evidence of a mouse‐like migratory stream
TLDR
The purpose of this work is to provide a reference for future studies in the field of adult neurogenesis that may lead to an understanding of the fate and functionality of newborn neurons in primates, and ultimately in humans.
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Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication
TLDR
This study provides the first demonstration that the PPN and CuN are innervated by dopamine transporter‐bearing fibres in normal monkeys, which points to a novel dopaminergic system that targets the lower brainstem.
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Consensus on the Definition of Advanced Parkinson's Disease: A Neurologists-Based Delphi Study (CEPA Study)
TLDR
A prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study), which will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition.
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Thymidine Analogs Are Transferred from Prelabeled Donor to Host Cells in the Central Nervous System After Transplantation: A Word of Caution
TLDR
It is shown for the first time that thymidine analog labeling may not be a reliable means of identifying transplanted cells, particularly in highly proliferative environments such as the developing, neurogenic, or injured brain.
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