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Individualized Dosimetry of Kidney and Bone Marrow in Patients Undergoing 177Lu-DOTA-Octreotate Treatment
TLDR
A method based on repeated whole-body imaging in combination with blood and urinary activity data over time was developed to determine the absorbed dose to the bone marrow, and the dose-limiting organ was the kidney in 197 of 200 patients.
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Studies of a Next-Generation Silicon-Photomultiplier–Based Time-of-Flight PET/CT System
TLDR
Excellent performance was achieved with the Discovery MI, including 375 ps FWHM coincidence time resolution and sensitivity of 14 cps/kBq, and comparisons between reconstruction algorithms and other multimodal silicon photomultiplier and non–silicon photomULTiplier PET detector system designs indicated that performance can be substantially enhanced with this next-generation system.
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Blood-brain barrier p-glycoprotein function in Alzheimer's disease
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Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging.
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Comparative Biodistribution and Radiation Dosimetry of 68Ga-DOTATOC and 68Ga-DOTATATE in Patients with Neuroendocrine Tumors
TLDR
There is no preference for either tracer for PET/CT evaluation of somatostatin receptor–expressing tumors from a radiation dosimetry point of view, and the effective dose for a typical 100-MBq administration of 68Ga-DOTATATE and 68 Ga-DotATOC is 2.1 mSv for both tracers.
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Evaluation of Tracer Kinetic Models for Quantification of P-Glycoprotein Function using (R)-[11C]Verapamil and PET
TLDR
The aim of the present study was to evaluate the kinetics of pure (R)-[11C]verapamil in humans and to develop a tracer kinetic model for the analysis of P-gp-mediated transport of (R), including the putative contribution of its radioactive metabolites.
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Dose Response of Pancreatic Neuroendocrine Tumors Treated with Peptide Receptor Radionuclide Therapy Using 177Lu-DOTATATE
TLDR
Evaluating the dose–response relationship for pancreatic neuroendocrine tumors treated with PRRT using 177Lu-DOTATATE implies a significant correlation between absorbed dose and tumor reduction.
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Pharmacokinetics and red cell utilization of 52Fe/59Fe‐labelled iron polymaltose in anaemic patients using positron emission tomography
TLDR
High red cell utilization of iron polymaltose occurred in anaemic patients and the reticuloendothelial uptake of this complex may reflect the safety of polysaccharide complexes.
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Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET
TLDR
New developments in positron emission tomography/computed tomography (PET/CT) include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent 18F–fluorodeoxyglucose (FDG) activity are described.
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Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigm
TLDR
The tau-specific PET tracer [18F]THK5317 images in vivo show the expected regional distribution of tau pathology, which contrasts with the different patterns of hypometabolism and amyloid-beta deposition.
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