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Recent research and development of Antrodia cinnamomea.
New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm.
Three new compounds are isolated from the ethyl acetate extract of Pteris ensiformis and show cytotoxicity against HL 60 cells (human leukemia) with the IC50 values of 3.7 and 8.7 μg/mL, respectively.
Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model.
Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.
- Keh-Min Liu, S. Chuang, Yung-Shun Juan
- BiologyAmerican journal of physiology. Renal physiology
- 15 August 2015
It is demonstrated that ketamine enhanced the generation of oxidative stress mediated by mitochondria- and ER-dependent pathways and consequently contributed to bladder apoptosis and urothelial lining defects.
Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al.
Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis and Perrottetia arisanensis and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.
Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway
The results of a set of experiments designed to reveal the underlying mechanism of DT cytotoxic activity against K562 cells suggested that DT can act as a topoisomerase II catalytic inhibitor, unlike the clinical anticancer drug, etoposide, which acts as aTopoisomersase poison.
Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress
The cytotoxic effect of isoaaptamine is associated with the induction of apoptosis and autophagy through oxidative stress and represents an interesting drug lead in the war against breast cancer.
The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
The investigation of the antitumor effect of the antioxidative ethanolic extract of R. cymosa fruits (RCE) along with its underlying mechanism of action suggested its potential application as an antileukemic dietary supplement.
Cladieunicellins K and L, New Eunicellin-Based Diterpenoids from an Octocoral Cladiella sp
- Fu-yuan Shih, Tsung-Hung Chen, P. Sung
- ChemistryInternational journal of molecular sciences
- 1 November 2013
Two new eunicellin-based diterpenoids, cladieunicellins K (1) and L (2), were isolated from an octocoral Cladiella sp. The structures of 1 and 2 were elucidated by spectroscopic methods and 2…
Isolation of marine bacteria with antimicrobial activities from cultured and field-collected soft corals
The results demonstrate that the marine bacteria from corals have great potential in the discovery of useful medical molecules.