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Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays.
Evaluation of a biased "library" of pyrrolo[2,3-d]pyrimidines using yeast-based functional assays expressing human A1- and A2a-adenosine receptors, led to the A1 selective antagonist 4b. A directExpand
Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1.
TLDR
expression of the PCPH and mt-PCPH proteins in Escherichia coli and the finding that the purified bacterial recombinant proteins have intrinsic guanosine diphosphatase (GDPase) activity are reported, suggesting the existence of significant functional differences between the mammalian and yeast enzymes. Expand
Signal-regulated Kinase ERK 1 Cooperates with Ras in Activating Extracellular Guanosine Diphosphatase Activity But Only the Oncoprotein Both Normal and Transforming PCPH Proteins Have
Previous reports from our laboratory described the activation of the PCPH gene into thePCPH oncogene (mt-PCPH, reported previously as Cph) by a single point mutational deletion. As a consequence, theExpand