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Regulation of T cell development by the deubiquitinating enzyme CYLD
The deubiquitinating enzyme CYLD is identified as a positive regulator of proximal T cell receptor signaling in thymocytes and physically interacted with active Lck and promoted recruitment of active Lk to its substrate, Zap70. Expand
Diabetes impairs the neuroprotective properties of retinal alpha-crystallins.
  • M. Losiewicz, P. Fort
  • Chemistry, Medicine
  • Investigative ophthalmology & visual science
  • 24 August 2011
The molecular properties of α-crystallins are disrupted by diabetes and contribute to the loss of neuroprotective function, which could lead to the emergence of new therapies for diabetic retinopathy. Expand
The Retinal Proteome in Experimental Diabetic Retinopathy
The use of complementary proteomics discovery methods coupled with targeted approaches to unveil new disease mechanistic details and therapeutic targets revealed that the proteins of the crystallin superfamily are increased dramatically in early diabetic retinopathy. Expand
Differential Roles of Hyperglycemia and Hypoinsulinemia in Diabetes Induced Retinal Cell Death: Evidence for Retinal Insulin Resistance
The results suggest that hyperglycemia induces resistance to growth factor action in the retina and clearly demonstrate that both restoration of glycemic control and retinal insulin signaling can act through different pathways to both normalize diabetes-induced retinal abnormality and prevent vision loss. Expand
Genetic Evidence for Sites of Interaction Between the Gal3 and Gal80 Proteins of the Saccharomyces cerevisiae GAL Gene Switch
The striking colocalization of intergenic suppressor residues and Gal80 nonbinder residues identifies a Gal3 surface that likely interacts with Gal80, and 12 single-amino-acid substitutions at residues that are predicted to be surface exposed on Gal3 are identified. Expand
mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes
Findings reveal distinctive responses of diabetes-induced retinal protein turnover compared with muscle and liver that may provide a new means to ameliorate diabetic retinopathy. Expand
Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis.
A novel mechanism regulating protein synthesis in the retina involving an mTORC1-independent and phosphatase-dependent regulation of 4E-BP1 is demonstrated. Expand
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
It is demonstrated that the inner retina expresses high levels of m TORC1 and mTORC2 and possesses active mTORc1 signaling that may provide cell- and tissue-specific regulation of homeostatic activity. Expand