The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase.
- Xingyuan Yang, Xin Lu, Jun Liu
- BiologyCell Metabolism
- 3 March 2010
The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology
- S. Viengchareun, D. Le Menuet, L. Martinerie, M. Munier, L. Pascual-Le Tallec, M. Lombès
- BiologyNuclear Receptor Signaling
- 1 January 2007
The structure, molecular mechanism of action and transcriptional regulation mediated by MR are described, emphasizing the most recent developments at the cellular and molecular level.
Pivotal role of the mineralocorticoid receptor in corticosteroid‐induced adipogenesis
- M. Caprio, B. Fève, Aurélie Claës, S. Viengchareun, M. Lombès, M. Zennaro
- Biology, MedicineThe FASEB Journal
- 1 July 2007
Results demonstrate that MR represents an important proadipogenic transcription factor that may mediate both aldosterone and glucocorticoid effects on adipose tissue development, and may be of pathophysiological relevance to the development of obesity and the metabolic syndrome.
The mineralocorticoid receptor: a journey exploring its diversity and specificity of action.
- L. Pascual-Le Tallec, M. Lombès
- BiologyMolecular Endocrinology
- 1 September 2005
The multiple levels of MR selectivity over other steroid receptors, in particular GR, will be described as well as the consequences for aldosterone-regulated gene expression.
Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure
- J. Nakae, Yongheng Cao, Y. Hayashi
- Biology, MedicineDiabetes
- 1 March 2008
These data suggest that FoxO1 modulates energy homeostasis in WAT and BAT through regulation of adipocyte size and adipose tissue–specific gene expression in response to excessive calorie intake.
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation.
- J. Bouligand, C. Ghervan, Jacques Young
- Biology, MedicineNew England Journal of Medicine
- 10 December 2009
A homozygous GNRH1 frameshift mutation results in an aberrant peptide lacking the conserved GnRH decapeptide sequence, as shown by the absence of immunoreactive GnRH when expressed in vitro.
Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2
- S. Viengchareun, N. Servel, B. Fève, M. Freemark, M. Lombès, N. Binart
- Biology, MedicinePLoS ONE
- 6 February 2008
It is reported that newborn mice lacking PRLR have hypotrophic BAT depots that express low levels of adipocyte nuclear receptor PPARγ2, its coactivator PGC-1α, uncoupling protein 1 (UCP1) and the β3 adrenoceptor, reducing mouse viability during cold challenge.
A key enzyme in the biosynthesis of neurosteroids, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD), is expressed in rat brain.
- R. Guennoun, R. Fiddes, M. Gouézou, M. Lombès, E. Baulieu
- BiologyBrain Research. Molecular Brain Research
- 1 June 1995
Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity:…
- L. Tallec, Olivier Kirsh, M. Lombès
- BiologyMolecular Endocrinology
- 1 December 2003
A novel function for PIAS1 is identified which interacts with the N-terminal domain of hMR and represses its ligand-dependent transcriptional activity, at least in part, through SUMO modifications.
Mineralocorticoid resistance
- M. Zennaro, M. Lombès
- Biology, MedicineTrends in endocrinology and metabolism
- 1 August 2004
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