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Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol‐sensitive TRPC cation channels
- T. Maier, M. Follmann, +11 authors C. Struebing
- Chemistry, Medicine
- British journal of pharmacology
- 1 July 2015
The cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia… Expand
Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension.
Hypertension and kidney damage in the double transgenic rat (dTGR) harboring both human renin and human angiotensinogen genes are dependent on the human components of the renin angiotensin system. We… Expand
Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte… Expand
Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor
Abstract—Recent advances in basic and clinical research have identified Rho kinase as an important target potentially implicated in a variety of cardiovascular diseases. Rho kinase is a downstream… Expand
Inhibition of Diacylglycerol–Sensitive TRPC Channels by Synthetic and Natural Steroids
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as… Expand
Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation.
- M. Loehn, Kerstin Steioff, M. Bleich, A. Busch, Yuri D. Ivashchenko
- Medicine, Chemistry
- European journal of pharmacology
- 10 January 2005
Vasoconstrictor factors, like urotensin, angiotensin and catecholamines, activate Rho-dependent serine-threonine kinase (Rho-kinase) and inhibition of this pathway represents a novel therapy for… Expand
INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters
To the Editor: Studies of human pancreatic islet biology are limited by restricted access to high-quality human islets. Therefore, rodent islets are commonly used as model systems, although they… Expand
Synthesis and Characterization of a Promising Novel FFAR1/GPR40 Targeting Fluorescent Probe for β-Cell Imaging.
- Romain Bertrand, A. Wolf, +6 authors O. Plettenburg
- Medicine, Biology
- ACS chemical biology
- 26 April 2016
Diabetes affects an increasing number of patients worldwide and is responsible for a significant rise in healthcare expenses. Imaging of β-cells bears the potential to contribute to an improved… Expand
Chronic vasopeptidase inhibition normalizes diabetic endothelial dysfunction.
- S. Schaefer, Kerstin Steioff, W. Linz, M. Bleich, A. Busch, M. Loehn
- European journal of pharmacology
- 26 January 2004
Type 2 diabetes mellitus is a major cause of vascular morbidity but animal models for this disease have not been adequately characterized. We demonstrate that endothelial dysfunction is present in… Expand
Cell Cycle Retardation in Monocytoid Cells Induced by Aminopeptidase N (CD13)
Aminopeptidase N (APN, CD13) is highly expressed on human monocytes. Activation of leucocyte subpopulations, such as T-cells, can induce CD13 expression. However, little is known about the… Expand