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X-14547A, a new ionophorous antibiotic produced by Streptomyces antibioticus NRRL 8167. Discovery, fermentation, biological properties and taxonomy of the producing culture.
TLDR
X-14547A is a novel antibiotic produced by a new strain of Streptomyces antibioticus (NRRL 8167) and is capable of complexing and transporting divalent as well as monovalent metal cations.
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Isolation and characterization of antibiotic X-14931A, the naturally occurring 19-deoxyaglycone of dianemycin.
Sir: A number of polyether antibiotics containing two spiroketal functions in their molecular structure are known. They include dianemycin1, lenoremycin2 (A-I30A)3', and leuseramycin (TM-531A)'). In…
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Microbial products. VI Five novel metabolites related to benz[a]anthracene from an unidentified actinomycete designated X-14881.
Five metabolites of actinomycete X-14881 were isolated from the fermentation broth and characterized. The major component was identified as [3R-(3 alpha,6a beta,7 beta,12 alpha,12a alpha)] or [3S-(3…
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Biosynthesis of aurodox (antibiotic X-5108). incorporation of 14C-labelled precursors into aurodox.
TLDR
The incorporation of 14Clabelled precursors into aurodox is described, which suggests that the antibiotic is in part derived from coupling of acetate units via the polyketide biosynthetic route.
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Novel polyether antibiotics X-14667A and X-14667B from Streptomyces cinnamonensis subsp. urethanofaciens. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the…
X-14667A and X-14667B are two novel polyether antibiotics produced by Streptomyces cinnamonensis subsp. urethanofaciens. The antibiotics are active in vitro against Gram-positive bacteria and exhibit…
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Three novel polyether antibiotics X-14889A, C, and D from a streptomycete. Taxonomy of the producing organism, fermentation production and biological properties of the antibiotics.
TLDR
Three novel polyether antibiotics related to lysocellin and antibiotic X-14873A are produced by a streptomycete isolated from a soil of Wisconsin and are active against Gram-positive bacteria and exhibits ionophore property.
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Structural Investigations of Mode of Action of Drugs: Structure and Conformation of a Novel Peptidyl Nucleoside Antibiotic Chryscandin Hydrochloride Pentahydrate†
TLDR
The structure and conformation of antibiotic chryscandin, a structural analog of the terminus 3′-aminoacyladenylate moiety of tRNA, has been determined and will be helpful in understanding structure-biological activity relationships, identification of inhibitors of metallopeptidases, and how chry scandin interacts with ribosomal units.
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