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Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
Despite the significance of Alzheimer’s disease, the link between metal-associated amyloid-β (metal–Aβ) and disease etiology remains unclear. To elucidate this relationship, chemical tools capable ofExpand
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Visualization of nitric oxide in living cells by a copper-based fluorescent probe
Nitric oxide (NO) serves as a messenger for cellular signaling. To visualize NO in living cells, we synthesized a turn-on fluorescent probe for use in combination with microscopy. Unlike existingExpand
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Crystallographic and spectroscopic characterization of a nonheme Fe(IV)-O complex.
Following the heme paradigm, it is often proposed that dioxygen activation by nonheme monoiron enzymes involves an iron(IV)=oxo intermediate that is responsible for the substrate oxidation step. SuchExpand
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Design of small molecules that target metal-Aβ species and regulate metal-induced Aβ aggregation and neurotoxicity
The accumulation of metal ions and amyloid-β (Aβ) aggregates found in the brain of patients with Alzheimer’s disease (AD) has been suggested to be involved in AD pathogenesis. To investigateExpand
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Small molecule modulators of copper-induced Abeta aggregation.
Our design of bifunctional metal chelators as chemical probes and potential therapeutics for Alzheimer's disease (AD) is based on the incorporation of a metal binding moiety into structuralExpand
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Metal-associated amyloid-β species in Alzheimer's disease.
  • A. Pithadia, M. Lim
  • Chemistry, Medicine
  • Current opinion in chemical biology
  • 1 April 2012
Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-β (Aβ) plaques within the brain of Alzheimer's disease (AD). In vitro and in vivo studies have suggested that metal binding toExpand
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TrkC plays an essential role in breast tumor growth and metastasis.
Tropomyosin-related kinase (Trk) C, a member of the Trk family of neurotrophin receptors, has been implicated in the growth and survival of human cancer tissues. Here, we report that TrkC isExpand
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Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage.
The mushroom Phellinus linteus has been known to exhibit potent biological activity. In contrast to the immuno-potentiating properties of Phellinus linteus, the anti-inflammatory properties ofExpand
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Sensitivity of Ru(bpy)2dppz2+ luminescence to DNA defects.
The luminescent characteristics of Ru(bpy)(2)dppz(2+) (dppz = dipyrido[3,2-a:2',3'-c]phenazine), a DNA light switch, were investigated in the presence of oligonucleotides containing single baseExpand
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Enzymes Responsible for Off‐Flavor and Off‐Aroma in Blanched and Frozen‐Stored Vegetables 1
Plant foods, stabilized by heating (blanching) until all peroxidase activity is destroyed and then frozen, may be stored frozen for 1 to 2 years without significant deterioration of texture, color,Expand
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