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Adding Insult to Injury: Cochlear Nerve Degeneration after “Temporary” Noise-Induced Hearing Loss
It is shown that acoustic overexposures causing moderate, but completely reversible, threshold elevation leave cochlear sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the co chlear nerve.
Auditory-nerve response from cats raised in a low-noise chamber.
- M. Liberman
- PhysicsThe Journal of the Acoustical Society of America
- 1 February 1978
The data suggest that there is a significant amount of "normal pathology" in the high-CF units from routine animals, and the possible significance of a classification of auditory-nerve units according to spontaneous rate is discussed.
Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates.
Responses from single auditory nerve fibers in guinea pigs exposed to neuropathic noise were recorded, suggesting recovery of hair cell function and a change in population statistics suggesting a selective loss of fibers with low- and medium-spontaneous rates.
Age-Related Cochlear Synaptopathy: An Early-Onset Contributor to Auditory Functional Decline
- Yevgeniya Sergeyenko, K. Lall, M. Liberman, S. Kujawa
- BiologyThe Journal of Neuroscience
- 21 August 2013
Age-related cochlear synaptic and neural degeneration in CBA/CaJ mice never exposed to high-level noise is characterized and key functional clues to the synaptopathy are available in the neural response; these can be accessed noninvasively, enhancing the possibilities for translation to human clinical characterization.
Primary Neural Degeneration in the Guinea Pig Cochlea After Reversible Noise-Induced Threshold Shift
- Harrison W. Lin, Adam C. Furman, S. Kujawa, M. Liberman
- BiologyJournal of the Association for Research in…
- 18 June 2011
The data cast doubt on prior claims that there is significant neural regeneration and synaptogenesis in the adult cochlea and suggest that denervation of the inner hair cell is an important sequela of “reversible” noise-induced hearing loss, which likely applies to the human ear as well.
Response properties of single auditory nerve fibers in the mouse.
In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR had higher thresholds, and wider dynamic ranges than fibers with high SR.
Single-neuron labeling and chronic cochlear pathology. III. Stereocilia damage and alterations of threshold tuning curves
Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
It is shown that targeted deletion of prestin in mice results in loss of outer hair cell electromotility in vitro and a 40–60 dB loss of cochlear sensitivity in vivo, without disruption of mechano-electrical transduction in outer hair cells.
Toward a Differential Diagnosis of Hidden Hearing Loss in Humans
The results suggest that the SP/AP ratio may be useful in the diagnosis of “hidden hearing loss” and that, as suggested by animal models, the noise-induced loss of cochlear nerve synapses leads to deficits in hearing abilities in difficult listening situations, despite the presence of normal thresholds at standard audiometric frequencies.
The cochlear frequency map for the cat: labeling auditory-nerve fibers of known characteristic frequency.
- M. Liberman
- BiologyThe Journal of the Acoustical Society of America
- 1 November 1982
The cochlear frequency map derived from these single-neuron labeling experiments is compared to maps derived by a number of different physiological and psychophysical techniques, and the significance of the similarities and differences is discussed.