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Testicular hypofunction caused by activating p53 expression induced by reactive oxygen species in varicocele rats
It is demonstrated that varicocele caused hypoxia that could cause the rise of ROS level to induce the increase of p53 expression, leading to the decrease of testis mass index and changes of seminiferous tubules, which would reduce sperm motility and result in male infertility eventually. Expand
Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm
Soluble granules of SJS could dramatically restore the CP-induced down-regulation of CatSper1 in epididymal spermatozoa, which greatly improved the sperm motility in the asthenozoospermic rats. Expand
Grape seed proanthocyanidin extract attenuates varicocele‑induced testicular oxidative injury in rats by activating the Nrf2‑antioxidant system.
Findings suggest that GSPE can ameliorate abnormal spermatogenesis and testicular injury in varicocele rats, potentially due to its antioxidative activity and ability to activate the Nrf2 pathway. Expand
DLX1, a binding protein of beta‐catenin, promoted the growth and migration of prostate cancer cells
It is demonstrated that DLX1 exerted the oncogenic roles on the prostate cancer by activating beta‐catenin/TCF signaling. Expand
Effects and mechanism of action of transcutaneous electrical acupuncture point stimulation in patients with abnormal semen parameters
It is suggested that 2 Hz TEAS can improve sperm count and motility in patients with abnormal semen parameters, and is associated with increases in seminal plasma zinc, NAG and fructose. Expand
CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells
It is suggested that CALB1 may act as an oncogene in ovarian cancer by inhibiting the p53 pathway by interacting with MDM2 proto-oncogene and promoting the interaction between p53 andMDM2. Expand
[Safety evaluation of the offspring conceived by assisted reproductive technology with donor's semen].
  • M. Liang, Bin Zhang, +6 authors Z. Li
  • Biology, Medicine
  • Zhonghua nan ke xue = National journal of…
  • 1 March 2011
There were no significant differences in the category of birth defects between ART with the donor's semen and that with the husband's, while the incidence of birth defect resulting fromART with the donors' semen was significantly lower than that from ICSI in infertile couples. Expand
AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells
An oncogenic role for AKAP2 in ovarian cancer is demonstrated, indicating thatAKAP2 may be a therapeutic target for ovarian cancer. Expand
AB256. Grape seed proanthocyanidin extract attenuates varicocele-induced testicular oxidative injury in rats by activating the Nrf2-antioxidant system
Background We investigated whether grape seed proanthocyanidin extract (GSPE) can attenuate varicocele-induced testicular oxidative injury through the Nrf2 antioxidant pathway. Methods A varicoceleExpand
Anti-oxidative and mitochondria-protective effects of extract of astragalus on focal cerebral ischemia-reperfusion injury in rats
EA had protective effects against focal cerebral ischemia reperfusion injuries via attenuating cerebral oxygen free radical(OFR)lipid peroxidation and protecting mitochondria. Expand