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Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressorExpand
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15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.
Prostaglandin J(2) (PGJ(2)) and its metabolites Delta(12)-PGJ(2) and 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) are naturally occurring derivatives of prostaglandin D(2) that have been suggested toExpand
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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
Significance Prion-like propagation of proteopathic seeds may underlie the progression of neurodegenerative diseases, including the tauopathies and synucleinopathies. Aggregate entry into the cell isExpand
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APOBEC3 proteins mediate the clearance of foreign DNA from human cells
Bacteria evolved restriction endonucleases to prevent interspecies DNA transmission and bacteriophage infection. Here we show that human cells possess an analogous mechanism. APOBEC3A is induced byExpand
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Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium
We generated two complementary systems for Cre‐mediated recombination of target genes in the mouse digestive epithelium and tested them with a Cre‐reporter mouse strain. Cre was expressed under theExpand
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MultiPipMaker and supporting tools: alignments and analysis of multiple genomic DNA sequences
We describe the MultiPipMaker server, which aligns multiple, long genomic DNA sequences quickly and with good sensitivity (available at http://bio.cse.psu.edu since May 2001). Expand
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Toxicological effects of TiO2 and ZnO nanoparticles in soil on earthworm Eisenia fetida.
Abstract Nanoparticles (NPs) of TiO 2 and ZnO are receiving increasing attention due to their widespread applications. To evaluate their toxicities to the earthworm Eisenia fetida (Savigny, 1826) inExpand
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Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor
The glucocorticoid (GC) receptor (GR), when liganded to GC, activates transcription through direct binding to simple (+)GRE DNA binding sequences (DBS). GC-induced direct repression via GR binding toExpand
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Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components.
  • M. Li, L. Zhu, D. Lin
  • Chemistry, Medicine
  • Environmental science & technology
  • 31 January 2011
Water chemistry can be a major factor regulating the toxicity mechanism of ZnO nanoparticles (nano-ZnO) in water. The effect of five commonly used aqueous media with various chemical properties onExpand
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Structural insights into energy regulation of light-harvesting complex CP29 from spinach
CP29, one of the minor light-harvesting complexes of higher-plant photosystem II, absorbs and transfers solar energy for photosynthesis and also has important roles in photoprotection. We have solvedExpand
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