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Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors
Group I metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with membersExpand
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  • Open Access
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
  • M. Li, B. Diep, +6 authors M. Otto
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 April 2009
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged worldwide. The United States, in particular, is experiencing a serious epidemic of CA-MRSA that isExpand
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The antimicrobial peptide‐sensing system aps of Staphylococcus aureus
Staphylococcus aureus is a leading cause of hospital‐associated and, more recently, community‐associated infections caused by highly virulent methicillin‐resistant strains (CA‐MRSA). S. aureusExpand
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Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B.
The three-dimensional structure of recombinant human monoamine oxidase A (hMAO A) as its clorgyline-inhibited adduct is described. Although the chain-fold of hMAO A is similar to that of rat MAO AExpand
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  • Open Access
Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must circumvent mechanisms of innate host defense. Antimicrobial peptides represent a key component of innate hostExpand
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  • Open Access
Retroviral DNA integration: reaction pathway and critical intermediates
The key DNA cutting and joining steps of retroviral DNA integration are carried out by the viral integrase protein. Structures of the individual domains of integrase have been determined, but theirExpand
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  • Open Access
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures
Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound enzyme that catalyzes the oxidative deamination of arylalkylamine neurotransmitters and has been a target for a number ofExpand
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  • Open Access
PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences
PDZ domains are multifunctional protein-interaction motifs that often bind to the C-terminus of protein targets. Nitric oxide (NO), an endogenous signaling molecule, plays critical roles in nervous,Expand
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G551D and G1349D, Two CF-associated Mutations in the Signature Sequences of CFTR, Exhibit Distinct Gating Defects
Mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR) result in cystic fibrosis (CF). CFTR is a chloride channel that is regulated by phosphorylation and gated byExpand
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Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants.
KCNQ potassium channels are activated by changes in transmembrane voltage and play an important role in controlling electrical excitability. Human mutations of KCNQ2 and KCNQ3 potassium channel genesExpand
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  • Open Access