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Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
It is demonstrated that tumour cells directly induce a myofibroblastic phenotype, and that this transdifferentiation is dependent on SCC-derived TGF-β1, and emphasises that cancer invasion can be promoted indirectly by the release of tumour-induced host factors from stroma. Expand
Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass system.
The solubility was seen to decrease with increasing CaO mol%, for all the glasses investigated, and all the compositions showed a gradual decrease in pH with time, and this was accounted for by the release of Na+ and Ca2+ ions into solution. Expand
Matrix metalloproteinases and oral cancer.
It is increasingly apparent that tumour cells, as well as producing endogenous MMP, are capable of utilising MMP produced by tumour stromal cells, indicating an active role for stroma in tumour invasion. Expand
Gelatinase-B (Matrix Metalloproteinase-9; MMP-9) secretion is involved in the migratory phase of human and murine muscle cell cultures
- M. Lewis, H. Tippett, A. Sinanan, M. Morgan, N. Hunt
- Biology, Medicine
- Journal of Muscle Research & Cell Motility
- 1 April 2000
Investigation of the activity of the gelatinases MMP-2 and 9 by zymography on cell conditioned media in cultures of cells derived from explants of the human masseter muscle and in the murine myoblast cell-line C2C12 shows consistent with the concept that regulation of matrix turnover via M MP-9 may be involved in the events leading to myotube formation, including migration. Expand
Betel‐derived alkaloid up‐regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis
The data suggest that the pathogenesis of OSF may be epithelial‐driven and involve arecoline‐dependent up‐regulation of αvβ6 integrin, raising the possibility that this mechanism may support malignant transformation. Expand
AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9.
It is found that increased expression of alphaVbeta6 in malignant keratinocytes up-regulates MMP-9 andMMP-2 expression and promotes invasion in an M MP-9-dependent manner. Expand
Craniofacial muscle engineering using a 3-dimensional phosphate glass fibre construct.
Investigation of the use of phosphate-based glass fibres as a potential scaffold material for the in vitro engineering of craniofacial skeletal muscle found a 3-dimensional mesh arrangement was the best at encouraging cell attachment and proliferation. Expand
Identification of matrix metalloproteinases and their tissue inhibitors type 1 and 2 in human masseter muscle.
- A. Singh, Z. Nelson-Moon, G. Thomas, N. Hunt, M. Lewis
- Chemistry, Medicine
- Archives of oral biology
- 1 June 2000
Investigation of in vivo pattern of expression and distribution of MMPs and TIMP proteins in masseter muscle of humans with both normal and abnormal facial forms provides evidence that the mechanisms required for matrix remodelling are present in the human masseter Muscle. Expand
The IGF‐I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle
The effects of muscle splice variants of insulin‐like growth factor I (IGF‐I) on proliferation and differentiation were studied in human primary muscle cell cultures from healthy subjects as well as from muscular dystrophy and ALS patients to potentially facilitate repair and maintenance of this postmitotic tissue. Expand
Human adult craniofacial muscle‐derived cells: neural‐cell adhesion‐molecule (NCAM; CD56)‐expressing cells appear to contain multipotential stem cells
The CD56+ subpopulation within adult human skeletal muscle is heterogeneous and is composed of both lineage‐committed myogenic cells and multipotent cells (the candidate MDSCs), which are able to form non‐muscle tissue such as fat and bone. Expand