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A prospective study of endogenous estrogens and breast cancer in postmenopausal women.
BACKGROUND Circumstantial evidence links endogenous estrogens to increased risk of breast cancer in women, but direct epidemiologic support is limited. In particular, only a few small prospectiveExpand
Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women
Experimental and epidemiological data support a role for sex steroid hormones in the pathogenesis of endometrial cancer. The associations of pre‐diagnostic blood concentrations of estradiol, estrone,Expand
Postmenopausal Levels of Endogenous Sex Hormones and Risk of Colorectal Cancer
Observational epidemiologic studies and randomized trials have reported a protective effect of oral hormonal replacement therapy on risk of colorectal cancer. Only one previous prospective study, theExpand
Breast-gut connection: origin of chenodeoxycholic acid in breast cyst fluid
The notion that a breast-gut connection might modulate the microenvironment of breast tissue was supported by the finding that breast cyst fluid contains bile acids that are characteristically foundExpand
Antipain and leupeptin restrict uterine DNA synthesis and function in mice.
As in rats, administration of estradiol to ovariectomized mice results in a trypsin-like proteolytic activity in the uterus. After fractionation of uteri from estradiol-treated ovariectomized miceExpand
Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study
We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case–control study nested within the NYU Women’sExpand
An estrogen-dependent esterase activity in MCF-7 cells.
The presence of steroidal esters in hormonally sensitive tissues lends importance to the esterases which convert the biologically inactive adducts to the parent potent forms. Accordingly,Expand
Effects of Parity on Pregnancy Hormonal Profiles Across Ethnic Groups with a Diverse Incidence of Breast Cancer
Epidemiologic evidence suggests that a full-term pregnancy may affect maternal risk of breast cancer later in life. The objective of this cross-sectional study was to compare circulating levels ofExpand
Conjugation of androgens and estrogens by human breast tumors in vitro
The metabolism of 3H-androstenedione (delta 4-A) and 3H-estriol (E3) was studied in 12 human breast tumors. Part of each tumor was analyzed for estrogen receptor content. Aliquots of tumorExpand
Conjugation and transfer of fetal-placental steroid hormones.
  • M. Levitz
  • Biology, Medicine
  • The Journal of clinical endocrinology and…
  • 1 July 1966
A Characteristic of human preg-nancy is the dramatic increase in production of certain protein and steroid hormones (1). The principal functions of these large amounts of hormones are not clearlyExpand